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El polimorfismo Taql A del gen del receptor D2 de la dopamina no se asocia con la búsqueda de novedad, la evitación del daño y la dependencia de la recompensa en los sujetos sanos

Published online by Cambridge University Press:  12 May 2020

B. de Brettes ,
I. Berlin ,
C. Laurent ,
J. P. Lépine ,
J. Mallet  and
A. J. Puech
B. de Brettes
Affiliation:
Servicio de Farmacología, Hospital Pitié-Salpêtrière, 47, Boulevard de l’Hôpital, 75013, Paris
I. Berlin
Affiliation:
Servicio de Farmacología, Hospital Pitié-Salpêtrière, 47, Boulevard de l’Hôpital, 75013, Paris
C. Laurent
Affiliation:
Laboratorio de Genética Molecular de la Neurotransmisión y de Procesos Neurodegenerativos C 9923 CNRS, Hospital Pitié-Salpêtrière
J. P. Lépine
Affiliation:
Servicio de Psiquiatría, Hospital Fernand Widal, París, Francia
J. Mallet
Affiliation:
Laboratorio de Genética Molecular de la Neurotransmisión y de Procesos Neurodegenerativos C 9923 CNRS, Hospital Pitié-Salpêtrière
A. J. Puech
Affiliation:
Servicio de Farmacología, Hospital Pitié-Salpêtrière, 47, Boulevard de l’Hôpital, 75013, Paris
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Resumen

Se ha encontrado que el alelo A1 del polimorfismo de longitud de fragmentos de restricción (RFLP) Taql A del gen del receptor D2 de dopamina está asociado con el abuso de sustancias y el alcoholismo. El rasgo de personalidad búsqueda de la novedad (BN) se asocia también con el abuso y la dependencia de sustancias. Sobre la base de la implicación de mecanismos dopaminérgicos en el abuso de sustancias, formamos la hipótesis de que la presencia del alelo A1 del gen del receptor D2 de dopamina puede representar una predisposición genérica para el rasgo de personalidad BN. Por tanto, investigamos si el alelo A1 del RFLP Tagí A del gen del receptor D2 de dopamina se asocia con la dimensión de BN del Cuestionario Tridimensional de la Personalidad (TPQ) en sujetos caucasianos sanos sin historia de abuso o dependencia de alcohol o sustancias. Determinamos el genotipo de 204 sujetos de 18 a 30 años edad. No hubo asociación entre ninguno de los alelos de los genes del receptor D2 y ninguna de las puntuaciones del TPQ (BN, Evitación del daño, Dependencia de la recompensa). Concluimos que el alelo A1 del RFLP Taql A del receptor D2 de dopamina no se asocia con el rasgo de personalidad BN en los sujetos caucasianos sanos.

Keywords

rasgos de personalidadgenotiporeceptor D2 de dopamina
Type
Comunicación Breve
Information
European Psychiatry (Ed. Española) , Volume 6 , Issue 4 , May 1999 , pp. 262 - 266
Copyright
Copyright © European Psychiatric Association 1999

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Footnotes

de BrettesB, BerlínI, LaurentC, LépineJP, MalletJ, PuechAJ. El polimorfismo Taql A del gen del receptor D2 de la dopamina no se asocia con la búsqueda de novedad, la evitación del daño y la dependencia de la recompensa en los sujetos sanos. Eur Psychiatry1998; 13: 427–30.

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