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SEIZURES IN WOMEN WITH PREECLAMPSIA: MECHANISMS AND MANAGEMENT

Published online by Cambridge University Press:  23 March 2011

MARILYN J CIPOLLA  and
RICHARD P KRAIG
MARILYN J CIPOLLA*
Affiliation:
Department of Neurology, University of Vermont
RICHARD P KRAIG
Affiliation:
Department of Neurology, University of Chicago
*
Marilyn J. Cipolla, PhD, Department of Neurology, University of Vermont, 89 Beaumont Ave. Given C454, Burlington, VT 05405. Email address: Marilyn.Cipolla@uvm.edu
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Extract

Eclampsia is defined in the obstetrical literature as the occurrence of unexplained seizure during pregnancy in a woman with preeclampsia. In the Western world, the incidence of eclampsia is ~1 per 2000 to 1 per 3000 pregnancies, but the incidence is 10-fold higher in tertiary referral centers and undeveloped countries where there is poor prenatal care, and in multi-fetal gestations. Nearly 1 in 50 women with eclampsia die as do 1 in 14 of their offspring, and mortality rates are considerably higher in undeveloped countries. Eclampsia is also associated with significant life-threatening complications, including neurological events. Seizure acutely can cause stroke, haemorrhage, oedema and brain herniation and thus lead to epilepsy and cognitive impairment later in life.

Type
Research Article
Information
Fetal and Maternal Medicine Review , Volume 22 , Issue 2 , May 2011 , pp. 91 - 108
Copyright
Copyright © Cambridge University Press 2011

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