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DK/Lm: A Strain of Laboratory Mouse with an Unusual Expression of the Lethal Yellow (Ay) Phenotype

Published online by Cambridge University Press:  14 April 2009

M. Lynn Lamoreux  and
Donald B. Galbraith
M. Lynn Lamoreux
Affiliation:
Department of Biology, Texas A & M University, College Station, Texas, USA77843
Donald B. Galbraith
Affiliation:
Trinity College, Hartford, Connecticut, USA06106
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Summary

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DK/Lm is a new inbred mouse strain with over 20 generations of brother–sister mating. The genotype of the DK/Lm mouse at the black-brown locus is b/b and heterozygosity at the agouti locus (Ay/a) is maintained. DK/Lm-Ay/a mice become sable in phenotype at the first moult, whereas C57BL/6J-Ay/a mice do not. The sable phenotype is defined as that of a mouse whose basic colour is yellow (phaeomelanic) but whose dorsal aspect is more or less darkened by the presence of nonyellow (eumelanic) pigment. At about 6 months of age the DK/Lm mouse gradually reverts to yellow in phenotype.

Mice of the two strains are compared. Observations are discussed and related to hypotheses regarding gene action at the a and e loci. The new strain is a useful experimental model for study of the relationship between gene action at the agouti locus and the important pleiotropic effects influenced by this locus.

Type
Research Article
Information
Genetics Research , Volume 48 , Issue 1 , August 1986 , pp. 35 - 40
Copyright
Copyright © Cambridge University Press 1986

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