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    Varshaver, Nina B. Marshak, Marina I. Gorbunova, Ludmila V. Lukash, Lubov L. and Shapiro, N.I. 1980. The synergistic effects of SV40 and BUdR on induction of gene mutations and chromosomal aberrations in chinese hamster cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 70, Issue. 3, p. 351.


Effect of pre-treatment with 5-bromouracil in an ultraviolet sensitive strain of Neurospora crassa

  • Arnold Nemerofsky (a1)
  • DOI:
  • Published online: 01 April 2009

5-Bromouracil was shown to enhance the mutation frequency in an ultraviolet sensitive strain of Neurospora crassa (uvs-2) that was previously irradiated with ultraviolet light. The design of the experiment eliminated light or dark repair as possible hypotheses to account for the observed enhancement. Since a similar effect was noted at the rib-1 locus in N. crassa, which is not a UV-sensitive strain, it appears that the error prone repair mechanism in N. crassa may be related to post-replication repair. This enhancement may be attributed to the interference of 5-bromouracil with post-replication repair. It is also postulated that the maximum increase in the mutation frequency occurs when the greatest number of unrepaired pre-mutational UV lesions are repaired in the presence of 5-bromouracil.

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Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
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