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The effects of inhibition of protein synthesis on the phenotype of Abnormal-abdomen*

Published online by Cambridge University Press:  14 April 2009

Ralph Hillman ,
Stephen J. Shafer  and
James H. Sang
Ralph Hillman
Affiliation:
Department of Biology, Temple University, Philadelphia, Pennsylvania, U.S.A., and School of Biology, University of Sussex, Brighton, England
Stephen J. Shafer
Affiliation:
Department of Biology, Temple University, Philadelphia, Pennsylvania, U.S.A., and School of Biology, University of Sussex, Brighton, England
James H. Sang
Affiliation:
Department of Biology, Temple University, Philadelphia, Pennsylvania, U.S.A., and School of Biology, University of Sussex, Brighton, England
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Penetrance and expressivity of the Drosophila mutant Abnormal-abdomen (A53g) may be reduced by adding inhibitors of protein synthesis, of RNA synthesis, and of oxidative phosphorylation to the defined, sterile medium on which larvae are developing. When grown on regular diet, the mutant flies contain a higher concentration of total protein than do wild-type flies. The metabolic inhibitors which reduce the expressivity of the mutation also lower protein concentration in these mutant flies. The reduction of protein synthesis is directly correlated with the reduction of expression of the mutant genotype. The regulation of the morphological abdominal abnormalities by the complex A53g genotype is discussed in relation to the control, by this same genetic system, of the mechanisms of protein synthesis.

Type
Research Article
Information
Genetics Research , Volume 21 , Issue 3 , June 1973 , pp. 229 - 238
Copyright
Copyright © Cambridge University Press 1973

References

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