Hostname: page-component-76fb5796d-vfjqv Total loading time: 0 Render date: 2024-04-28T08:09:05.879Z Has data issue: false hasContentIssue false
  • English
  • Français

A gene triplet in the mouse*

Published online by Cambridge University Press:  14 April 2009

A. G. Searle  and
Gillian M. Truslove
A. G. Searle
Affiliation:
M.R.C. Radiobiology unit, Harwell, Berks.
Gillian M. Truslove
Affiliation:
M.R.C. Experimental Genetics Unit, University College London
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Mice heterozygous for rump-white (Rw) have white hair in lumbo-sacral and caudal regions, although the tail-tip is sometimes pigmented. The homozygote is lethal in utero. No recombination has been found between Rw and the very closely linked spotting genes patch (Ph) and the viable allele of W (Wv). The compounds between these genes are all viable and fertile, although individual homozygotes are either lethal (Ph, Rw) or sterile and anaemic (Wv). It is concluded that they are non-allelic, but form a gene triplet. Close linkage between a cluster of dominant spotting genes and an angora gene in mouse and rabbit provide evidence for homology of part of linkage group II in the rabbit and part of linkage group XVII in the mouse.

Type
Research Article
Information
Genetics Research , Volume 15 , Issue 2 , April 1970 , pp. 227 - 235
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Batchelor, A. L., Phillips, R. J. S. & Searle, A. G. (1966). A comparison of the mutagenie effectiveness of chronic neutron- and γ-irradiation of mouse spermatogonia. Mutation Res. 3, 218–229.CrossRefGoogle ScholarPubMed
Dickie, M. M. (1966). Personal communication. Mouse News Lett. 34, 30.Google Scholar
Flanagan, S. P. & Isaacson, J. H. (1967). Close linkage between genes which cause hairlessness in the mouse. Genet. Res., Camb. 9, 99–110.Google Scholar
Green, E. L. (1966). Ed. Biology of the Laboratory Mouse, 2nd edn.New York, McGraw-Hill.Google Scholar
Grüneberg, H. (1942). Inherited macrocytic anaemias of the house mouse. II. Dominance relationships. J. Genet. 43, 285–293.CrossRefGoogle Scholar
Grüneberg, H. & Truslove, G. M. (1960). Two closely linked genes in the mouse. Genet. Res., Camb. 1, 69–90.CrossRefGoogle Scholar
Petras, M. & Biddle, F. G. (1966). Serum esterases in the house mouse, Mus musculus. Can. J. Genet. Cytol. 9, 704–710.Google Scholar
Popp, R. A. (1967). Linkage of Es-1 and Es-2 in the mouse. J. Hered. 58, 186–188.CrossRefGoogle Scholar
Robinson, R. (1958). Genetics of the rabbit. Biblio, genet. 17, 229–558.Google Scholar
Russell, L. B. & Russell, W. L. (1960). Genetic analysis of induced deletions and of spontaneous non-disjunctions involving chromosome 2 of the mouse. J. cell. comp. Physiol. 56, suppl. 1, 169–188.Google Scholar
Sobels, F. H. (1969). Recent advances in radiation genetics with emphasis on repair phenomena. Proc. XII Intern. Congr. Genet., Tokyo, 2, 28–29.Google Scholar