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‘Heterosis’ in litter size of chimaeric mice

Published online by Cambridge University Press:  14 April 2009

Hitoshi Mikami  and
Akira Onishi
Hitoshi Mikami
Affiliation:
Department of Animal Breeding and Genetics, National Institute of Animal Industry, Tsukuba, Ibaraki, 305, Japan
Akira Onishi
Affiliation:
Department of Animal Breeding and Genetics, National Institute of Animal Industry, Tsukuba, Ibaraki, 305, Japan
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Aggregation chimaeras were made from embryos of C57BL/6 and BALB/c mice. Chimaeric and control females were mated with ICR males at 8 weeks of age and their litter sizes were evaluated over a 5-month period after the first mating. Progeny tests showed that 18 of 27 chimaeras produced oocytes of both genotypes. The mean litter sizes of C57BL/6, BALB/c and their F1 crosses (C57BL/6 × BALB/c and BALB/c × C57BL/6) were 8·14, 9·36, 13·38 and 13·40, respectively. The mean for chimaeras was 11·54 and chimaeric heterosis was evident, but it was not as much as heterosis in the F1 When the chimaeras were classified into the mixed and single-genotype progeny chimaeras, chimaeric heterosis was observed only in the mixed-progeny chimaeras. Quantitative GPI analyses in ten organs showed that the degree of chimaerism in the mixed-genotype progeny chimaeras was higher than that in most of the single-genotype progeny chimaeras and that the degree of chimaerism in the ovaries was positively correlated with litter size in the mixed-genotype progeny chimaeras. On the other hand, such correlation was not observed in the single-genotype progeny chimaeras.

Type
Research Article
Information
Genetics Research , Volume 46 , Issue 1 , August 1985 , pp. 85 - 94
Copyright
Copyright © Cambridge University Press 1985

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