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Inheritance of Scottish-type resistance to warfarin in the Norway rat

Published online by Cambridge University Press:  14 April 2009

J. H. Greaves  and
P. B. Ayres
J. H. Greaves
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey
P. B. Ayres
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey
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The inheritance of resistance to the rodenticide, warfarin, in the Norway rat, Rattus norvegicus, derived from a wild rat population in Scotland was studied in the backcross, intercross and testcross. The resistance was found to be due to a major gene with about the same map position in Linkage Group I as the warfarin-resistance gene, Rw2, which occurs in the wild rat population in Wales. In heterozygotes, the Scottish resistance gene, unlike the Welsh gene, is incompletely penetrant in expression, though the penetrance was found to increase markedly in response to selection. Differences between the Scottish and Welsh types of resistance suggest that the two resistance genes are allelic.

Type
Research Article
Information
Genetics Research , Volume 28 , Issue 3 , December 1976 , pp. 231 - 239
Copyright
Copyright © Cambridge University Press 1976

References

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