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Mutant alleles of the meiotic locus, mei-9, differ in degree of effects on rod chromosome magnification and ring chromosome transmission in Drosophila

Published online by Cambridge University Press:  14 April 2009

Donald J. Komma ,
Heath Graves  and
Sharyn A. Endow
Donald J. Komma
Affiliation:
Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina27710
Heath Graves
Affiliation:
Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina27710
Sharyn A. Endow*
Affiliation:
Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina27710
*
* Corresponding author.
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Two mutant alleles of the meiotic locus, mei-9, have been examined for their effect on magnification of a rod Xbb chromosome and transmission of a ring Xbb chromosome under magnifying conditions. Our results indicate that the effects of these two mutations are allele-specific: mei-9a strongly inhibits both rod chromosome magnification and ring chromosome loss under magnifying conditions, while mei-9b has a smaller inhibitory effect on rod chromosome magnification and on the transmission of ring chromosomes under magnifying conditions. These observations can be explained by a difference in leakiness between the two alleles. Our results demonstrate that mutants defective in excision repair and repair replication inhibit ribosomal gene magnification. This suggests that a component of the excision repair pathway is involved in the process of magnification.

Type
Research Article
Information
Genetics Research , Volume 53 , Issue 3 , June 1989 , pp. 155 - 161
Copyright
Copyright © Cambridge University Press 1989

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