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The reduction in fitness from genetic drift at heterotic loci in small populations

Published online by Cambridge University Press:  14 April 2009

Alan Robertson
Alan Robertson
Affiliation:
Institute of Animal Genetics, Edinburgh
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Summary

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In finite populations, loci maintained segregating by hétérozygote superiority will be disturbed from their equilibrium positions by genetic sampling and the mean fitness of individuals will consequently be reduced. A general expression for this reduction is obtained for the segregation of two alleles. If the probability of continued segregation at the locus is high, the reduction tends to 1/4N, irrespective of the strength of selection, where N is the effective population size. This will always be much less than the segregation load. If n alleles are segregating, so that all heterozygotes have the same fitness, the reduction tends to (n−1)/4N.

Type
Short Papers
Information
Genetics Research , Volume 15 , Issue 2 , April 1970 , pp. 257 - 259
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

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