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The coalescent process in models with selection, recombination and geographic subdivision

  • Norman Kaplan (a1), Richard R. Hudson (a2) and Masaru Iizuka (a3)
  • DOI:
  • Published online: 01 April 2009

A population genetic model with a single locus at which balancing selection acts and many linked loci at which neutral mutations can occur is analysed using the coalescent approach. The model incorporates geographic subdivision with migration, as well as mutation, recombination, and genetic drift of neutral variation. It is found that geographic subdivision can affect genetic variation even with high rates of migration, providing that selection is strong enough to maintain different allele frequencies at the selected locus. Published sequence data from the alcohol dehydrogenase locus of Drosophila melanogaster are found to fit the proposed model slightly better than a similar model without subdivision.

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J. G. Oakeshott , J. B. Gibson , P. R. Anderson , W. R. Knibb , D. G. Anderson & G. K. Chambers (1982). Alcoholdehydrogenaseandglycerol-3-phosphatedehydro-genase clines in Drosophila melanogaster on three continents. Evolution 36, 8696.

S. Tavaré (1984). Line-of-descent and genealogical processes, and their applications in population genetic models. Theoretical Population Biology 26, 119164.

C. L. Vigue & F. M. Johnson (1973). Isozyme variability in species of the genus Drosophila. VI. Frequency – Property – Environment relationships of allelic alcohol dehydrogenases in D. melanogaster. Biochemical Genetics 9, 213227.

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