Skip to main content Accessibility help

Additive Effect of Enterococcus faecium on Enterococcal Bloodstream Infections: A 14-Year Study in a Swiss Tertiary Hospital

  • Maja Weisser (a1), Selja Capaul (a2), Marc Dangel (a1), Luigia Elzi (a1), Esther Kuenzli (a1), Reno Frei (a2) and Andreas Widmer (a1)...


We investigated whether an increase in enterococcal bloodstream infections (BSIs) depends on the emergence of Enterococcus faecium in an area with low vancomycin-resistant enterococci prevalence. From 1999 to 2012, a linear increase in E. faecium BSI rates (0.009 per 1,000 patient-days per year; P<.001) was noted. Enterococcus faecalis BSI rates remained stable.


Corresponding author

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland (


Hide All
1.Moellering, RC JrEmergence of Enterococcus as a significant pathogen. Clin Infect Dis 1992;14(6):11731176.
2.Murdoch, DR, Mirrett, S, Harrell, LJ, Monahan, JS, Reller, LB. Sequential emergence of antibiotic resistance in enterococcal bloodstream isolates over 25 years. Antimicrob Agents Chemother 2002;46(11):36763678. Regt, MJ, van der Wagen, LE, Top, J, et al.High acquisition and environmental contamination rates of CC17 ampicillin-resistant Enterococcus faecium in a Dutch hospital. J Antimicrob Chemother 2008;62(6):14011406.
4. Swiss Center for Antibiotic Resistance (anresis). anresis annual report 2013. Bern: anresis, 2013.
5.Homan, WL, Tribe, D, Poznanski, S, et al.Multilocus sequence typing scheme for Enterococcus faecium. J Clin Microbiol 2002;40(6):19631971.
6.Top, J, Schouls, LM, Bonten, MJ, Willems, RJ. Multiple-locus variable-number tandem repeat analysis: a novel typing scheme to study the genetic relatedness and epidemiology of Enterococcus faecium isolates. J Clin Microbiol 2004;42(10):45034511.
7.Boyce, JM, White, RL, Spruill, EY. Impact of methicillin-resistant Staphylococcus aureus on the incidence of nosocomial staphylococcal infections. J Infect Dis 1983;148(4):763.
8.Ammerlaan, HS, Harbarth, S, Buiting, AG, et al.Secular trends in nosocomial bloodstream infections: antibiotic-resistant bacteria increase the total burden of infection. Clin Infect Dis 2013;56(6):798805.
9.Willems, RJ, Top, J, van Santen, M, et al.Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complex. Emerg Infect Dis 2005;11(6):821828.
10.Senn, L. Unprecedented nosocoimal spread of vancomycin-resistant Enterococcus faecium in a tertiary-care hospital in Switzerland. Paper presented at: BMC Proceedings, 2011, Geneva.


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed