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An Outbreak of Serratia marcescens Bloodstream Infections Associated With Misuse of Drug Vials in a Surgical Ward

Published online by Cambridge University Press:  21 June 2016

Angelo Pan ,
Lucia Dolcetti ,
Catia Barosi ,
Patrizia Catenazzi ,
Tomaso Ceruti ,
Lucio Ferrari ,
Silvia Magri ,
Eugenia Quiros Roldan ,
Laura Soavi  and
Giuseppe Carnevale
Angelo Pan*
Affiliation:
Divisione di Malattie Infettive, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy Istituto di Malattie Infettive e Tropicali, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
Lucia Dolcetti
Affiliation:
Direzione Sanitaria, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
Catia Barosi
Affiliation:
Servizio di Farmacia, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
Patrizia Catenazzi
Affiliation:
Direzione Sanitaria, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
Tomaso Ceruti
Affiliation:
Laboratorio di Microbiologia, Istituti Ospitalieri di Cremona, Cremona, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
Lucio Ferrari
Affiliation:
Laboratorio di Microbiologia, Istituti Ospitalieri di Cremona, Cremona, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
Silvia Magri
Affiliation:
Istituto di Malattie Infettive e Tropicali, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
Eugenia Quiros Roldan
Affiliation:
Istituto di Malattie Infettive e Tropicali, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
Laura Soavi
Affiliation:
Istituto di Malattie Infettive e Tropicali, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
Giuseppe Carnevale
Affiliation:
Divisione di Malattie Infettive, Spedali Civili, Università degli Studi di Brescia, Brescia, Italy
*
Istituto di Malattie Infettive e Tropicali, Spedali Civili- Universita degli Studi di Brescia, Piazzale Spedali Civili, 1, 20123 Brescia, Italy (ange.pan@tiscali.it)
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Abstract

We report an outbreak of Serratia marcescens bloodstream infection due to contamination of total parenteral nutrition solution by insulin or poligeline solution when single-use vials were used for multiple doses in a surgical ward. Four patients had severe sepsis, and no patient died. Multidose vials, used either correctly or incorrectly, may be associated with bloodstream infection.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 1 , January 2006 , pp. 79 - 82
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

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References

1.Alfizah, H, Nordiah, AJ, Rozaidi, WS. Using pulse-field gel electrophoresis in the molecular investigation of an outbreak of S. marcescens infection in an intensive care unit. Singapore Med J 2004; 45:214–218.Google Scholar
2.Furusyo, N, Kubo, N, Nakashima, H, Kashigawi, K, Etoh, Y, Hayashi, J. Confirmation of nosocomial hepatitis C virus infection in a hemodialysis unit. Infect Control Hosp Epidemiol 2004; 25:584–590.CrossRefGoogle Scholar
3.Grohskopf, LA, Roth, VR, Feikin, DR, et al. Serratia liquefaciens bloodstream infections from contamination of epoietin alfa at a hemodialysis center. N Engl J Med 2001; 344:1491–1497.CrossRefGoogle Scholar
4.Magee, L, Godsiff, L, Matthew, I, Farrington, M, Park, GR. Anesthetic drugs and bacterial contamination. Eur J Anaesthesiol Suppl 1995; 12:41–43.Google ScholarPubMed
5.Pegues, DA, Arathoon, EG, Samoya, B, et al. Epidemic gram-negative bacteremia in a neonatal intensive care unit in Guatemala. Am J Infect Control 1994; 22:163–171.CrossRefGoogle Scholar
6.Kirschke, DL, Jones, TF, Craig, AS, et al. Pseudomonas aeruginosa and Serratia marcescens contamination associated with a manufacturing defect in bronchoscopes. N Engl J Med 2003; 348:214–220.CrossRefGoogle ScholarPubMed
7.Miranda-Novales, MG, Gordillo-Perez, MG, Solorzano-Santos, F, Leanos-Miranda, B, Villasis-Keever, MA, Villegas-Silva, R. Case-control study of an outbreak of S. marcescens in a neonatal intensive care unit [in Spanish]. Rev Invest Clin 1998; 50:13–18.Google Scholar
8.Boyce, JM, Pittet, D. Guideline for hand hygiene in health-care settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/API/IDSA Hand Hygiene Task Force. MMWR Recomm Rep 2002; 51:1–45.Google Scholar
9.Pittet, D, Mourouga, P, Perneger, TV, et al. Compliance with hand washing in a teaching hospital. Ann Intern Med 1999; 130:126–130.CrossRefGoogle ScholarPubMed
10.National Committee for Clinical Laboratory Standards. Approved standard M7-A5: methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 5th ed. Villanova, PA: National Committee for Clinical Laboratory Standards, 2000.Google Scholar
11.Levy, MM, Fink, MP, Marshall, JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003; 29:530–538.CrossRefGoogle ScholarPubMed
12.Jang, TN, Fung, CP, Yang, TL, Shen, SH, Huang, CS, Lee, SH. Use of pulsed-field gel electrophoresis to investigate an outbreak of Serratia marcescens infection in a neonatal intensive care unit. J Hosp Infect 2001; 48:13–19.CrossRefGoogle Scholar
13.Wilhelmi, I, Bernaldo de Quiros, JC, Romero-Vivas, J, Duarte, J, Rojo, E, Bouza, E. Epidemic outbreak of Serratia marcescens infection in a cardiac surgery unit. J Clin Microbiol 1987; 25:1298–1300.CrossRefGoogle Scholar
14.Pittet, D, Hugonnet, S, Harbarth, S, et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet 2000; 356:1307–1312.CrossRefGoogle ScholarPubMed
15.Blogg, CE, Ramsay, MA, Jarvis, JD. Infection hazard from syringes. Br J Anaesth 1974;46:260–262.CrossRefGoogle ScholarPubMed
16.Haddy, RI, Mann, BL, Nadkarni, DD, et al. Nosocomial infection in the community hospital: severe infection due to Serratia species. J Earn Pract 1996; 42:273–277.Google ScholarPubMed
17.Yu, WL, Lin, CW, Wang, DY. Serratia marcescens bacteremia: clinical features and antimicrobial susceptibilities of the isolates. J Microbiol Immunol Infect 1998; 31:171–179.Google ScholarPubMed
18.Bochud, PY, Calandra, T. Pathogenesis of sepsis: new concepts and implications for future treatment. BMJ 2003; 326:262–266.CrossRefGoogle ScholarPubMed
19.Harbarth, S, Garbino, J, Pugin, J, Romand, JA, Lew, D, Pittet, D. Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis. Am J Med 2003; 115:529–535.CrossRefGoogle Scholar