1.Klevens RM, Edwards IR, Richards CL Jret al.Estimating health care–associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 2007;122(2):160–166.
2.Roberts RR, Scott RD IIHota B, et al.Costs attributable to healthcare-acquired infection in hospitalized adults and a comparison of economic methods. Med Care 2010;48(11):1026–1035.
3.Lucado J, Gould C, Elixhauser A. Clostridium difficile infections (CDI) in hospital stays, 2009. Statistical brief 124. Rockville, MD: Healthcare Cost and Utilization Project Statistical Briefs, 2012.
4.Dubberke ER, Wertheimer AI. Review of current literature on the economic burden of Clostridium difficile infection. Infect Control Hosp Epidemiol 2009;30(1):57–66.
5.Kyne L, Hamel MB, Polavaram R, Kelly CP. Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis 2002;34(3):346–353.
6.Dubberke ER, Butler AM, Reske KA, et al.Attributable outcomes of endemic Clostridium difficile–associated disease in nonsurgical patients. Emerg Infect Dis 2008;14(7):1031–1038.
7.Dubberke ER, Reske KA, Olsen MA, McDonald LC, Fraser VJ. Short- and long-term attributable costs of Clostridium difficile–associated disease in nonsurgical inpatients. Clin Infect Dis 2008;46(4):497–504.
8.O'Brien IA, Lahue BJ, Caro JJ, Davidson DM. The emerging infectious challenge of Clostridium difficile–associated disease in Massachusetts hospitals: clinical and economic consequences. Infect Control Hosp Epidemiol 2007;28(11):1219–1227.
9.Miller M, Gravel D, Mulvey M, et al.Health care–associated Clostridium difficile infection in Canada: patient age and infecting strain type are highly predictive of severe outcome and mortality. Clin Infect Dis 2010;50(2):194–201.
10.Lawrence SJ, Puzniak LA, Shadel BN, Gillespie KN, Kollef MH, Mundy LM. Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol 2007;28(2):123–130.
11.Kilgore ML, Ghosh K, Beavers CM, Wong DY, Hymel PA JrBrossette SE. The costs of nosocomial infections. Med Care 2008;46(1):101–104.
12.Zilberberg MD, Tabak YP, Sievert DM, et al.Using electronic health information to risk-stratify rates of Clostridium difficile infection in US hospitals. Infect Control Hosp Epidemiol 2011;32(7):649–655.
13.Tabak YP, Johannes RS, Silber JH. Using automated clinical data for risk adjustment: development and validation of six disease-specific mortality predictive models for pay-for-performance. Med Care 2007;45(8):789–805.
14.Tabak YP, Sun X, Derby KG, Kurtz SG, Johannes RS. Development and validation of a disease-specific risk adjustment system using automated clinical data. Health Serv Res 2010;45:1815–1835.
16.Parsons LS, ed. Reducing bias in a propensity score matched-pair sample using greedy matching techniques. In: Proceedings of the 26th Annual SAS Users Group International Conference. Long Beach, CA: SAS Institute, 2001.
17.Austin PC. Comparing paired vs non-paired statistical methods of analyses when making inferences about absolute risk reductions in propensity-score matched samples. Stat Med 2011;30(11):1292–1301.
18.Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. 3rd ed. Philadelphia: Lippincott-Wolters-Kluwer, 2008.
19.Sato T. On the variance estimator for the Mantel-Haenszel risk difference. Biometrics 1989;45:1323–1324.
20.Sullivan LM, Dukes KA, Losina E. Tutorial in biostatistics: an introduction to hierarchical linear modelling. Stat Med 1999;18(7):855–888.
21.Efron B, Tibshirani R. An Introduction to the Bootstrap. London: Chapman & Hall, 1993.
22.Dubberke ER, Butler AM, Yokoe DS, et al.Multicenter study of surveillance for hospital-onset Clostridium difficile infection by the use of ICD-9-CM diagnosis codes. Infect Control Hosp Epidemiol 2010;31(3):262–268.
23.Dallal RM, Harbrecht BG, Boujoukas AJ, et al.Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg 2002;235(3):363–372.
24.Miller MA, Hyland M, Ofner-Agostini M, Gourdeau M, Ishak M. Morbidity, mortality, and healthcare burden of nosocomial Clostridium difficile–associated diarrhea in Canadian hospitals. Infect Control Hosp Epidemiol 2002;23(3):137–140.
25.Loo VG, Poirier L, Miller MA, et al.A predominantly clonal multi-institutional outbreak of Clostridium difficile–associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353(23):2442–2449.
26.Pepin J, Valiquette L, Cossette B. Mortality attributable to nosocomial Clostridium difficile–associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ 2005;173(9):1037–1042.
27.Forster AJ, Taljaard M, Oake N, Wilson K, Roth V, van Walraven C. The effect of hospital-acquired infection with Clostridium difficile on length of stay in hospital. CMAJ 2012;184(1):37–42.
28.Cohen SH, Gerding DN, Johnson S, et al.Clinical practice guide-lines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010;31(5):431–455.
29.Centers for Disease Control and Prevention. Vital signs: preventing Clostridium difficile infections. MMWR Morb Mortal Wkly Rep 2012;61(9):157–162.
30.Centers for Medicare and Medicaid Services. Medicare program; hospital inpatient prospective payment systems for acute care hospitals and the long-term care hospital prospective payment system and FY 2012 rates; hospitals' FTE resident caps for graduate medical education payment. Final rules. Fed Regist 2011;76(160):51476–51843.