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Diminished Susceptibility to Daptomycin Accompanied by Clinical Failure in a Patient With Methicillin-Resistant Staphylococcus aureus Bacteremia

Published online by Cambridge University Press:  21 June 2016

David Hirschwerk ,
Christine C. Ginocchio ,
Maureen Bythrow  and
Susan Condon
David Hirschwerk*
Affiliation:
Department of Medicine, New York University School of Medicine, and Division of Infectious Diseases, North Shore University Hospital, Manhasset, New York
Christine C. Ginocchio
Affiliation:
Microbiology, Virology, and Molecular Diagnostics, Department of Laboratory Medicine, Lake Success, New York
Maureen Bythrow
Affiliation:
Department of Microbiology, North Shore-Long Island Jewish Health System Laboratories, Lake Success, New York
Susan Condon
Affiliation:
Department of Microbiology, North Shore-Long Island Jewish Health System Laboratories, Lake Success, New York
*
Division of Infectious Diseases, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030 (dhirsch@nshs.edu)
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Abstract

We cared for a patient with methicillin-resistant Staphylococcus aureus bacteremia who experienced clinical failure with daptomycin. The failure was accompanied by progressive elevation of the daptomycin minimum inhibitory concentration during treatment. DNA fingerprinting confirmed that the minimum inhibitory concentration elevation occurred within the same strain of methicillin-resistant Staphylococcus aureus. This observation provides important new information to clinicians who adopt this promising drug for treatment of serious infections caused by methicillin-resistant Staphylococcus aureus.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 3 , March 2006 , pp. 315 - 317
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

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