Skip to main content Accessibility help
×
×
Home

Diminished Susceptibility to Daptomycin Accompanied by Clinical Failure in a Patient With Methicillin-Resistant Staphylococcus aureus Bacteremia

  • David Hirschwerk (a1), Christine C. Ginocchio (a2), Maureen Bythrow (a3) and Susan Condon (a3)

Abstract

We cared for a patient with methicillin-resistant Staphylococcus aureus bacteremia who experienced clinical failure with daptomycin. The failure was accompanied by progressive elevation of the daptomycin minimum inhibitory concentration during treatment. DNA fingerprinting confirmed that the minimum inhibitory concentration elevation occurred within the same strain of methicillin-resistant Staphylococcus aureus. This observation provides important new information to clinicians who adopt this promising drug for treatment of serious infections caused by methicillin-resistant Staphylococcus aureus.

Copyright

Corresponding author

Division of Infectious Diseases, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030 (dhirsch@nshs.edu)

References

Hide All
1.Chang, S, Sievert, DM, Hageman, JC, et al. Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene. N Engl J Med 2003; 348:13421347.
2.Howden, BP, Ward, PB, Charles, PGP, et al. Treatment outcomes for serious infections caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility. Clin Infect Dis 2004; 38:521528.
3.Carpenter, CF, Chambers, HF. Daptomycin: another novel agent for treating infections due to drug-resistant gram-positive pathogens. Clin Infect Dis 2004; 38:9941000.
4.Akins, RL, Rybak, MJ. Bactericidal activities of two daptomycin regimens against clinical strains of glycopeptide intermediate-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and methicillin-resistant Staphylococcus aureus isolates in an in vitro pharmacodynamic model with simulated endocardial vegetations. Antimicrob Agents Chemother 2001; 45:454459.
5.Cubicin (daptomycin for injection) [package insert]. Lexington, MA: Cubist Pharmaceuticals; 2003.
6.LaPlante, KL, Rybak, MJ. Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model. Antimicrob Agents Chemother 2004; 48:44654472.
7.Cha, R, Rybak, MJ. Daptomycin against multiple drug-resistant Staphylococcus and Enterococcus isolates in an in vitro pharmacodynamic model with simulated endocardial vegetations. Diagn Microbiol Infect Dis 2003; 47:539546.
8.Steenbergen, JN, Alder, J, Thome, GM, Tally, FP. Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections. J Antimicrob Chemother 2005; 55:283288.
9.Sakoulas, G, Eliopoulos, GM, Adler, J, Thauvin-Eliopoulos, C. Efficacy of daptomycin in experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2003; 47:17141718.
10.Rand, KH, Houck, HJ. Synergy of daptomycin with oxacillin and other B-lactams against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2004; 48:28712875.
11.Mohan, SS, Mcdermott, BP, Cunha, BA. Methicillin-resistant Staphylococcus aureus prosthetic valve endocarditis with paravalvular abscess treated with daptomycin. Heart Lung 2005; 34:6971.
12.Silverman, JA, Oliver, N, Andrew, T, Li, T. Resistance studies with daptomycin. Antimicrob Agents Chemother 2001; 45:17991802.
13.Mangilli, A, Bica, I, Snydman, DR, Hamer, DH. Daptomycin-resistant, methicillin-resistant, Staphylococcus aureus bacteremia. Clin Infect Dis 2005; 40:10581060.
14.Wise, R, Andrews, JM, Ashby, JP. Activity of daptomycin against gram-positive pathogens: a comparison with other agents and the determination of a tentative breakpoint. J Antimicrob Chemother 2001; 48:563567.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed