1. Slimings, C, Riley, TV. Antibiotics and hospital-acquired Clostridium difficile infection: update of systematic review and meta-analysis. J Antimicrob Chemother 2014;69:881–891.
2. Smits, WK, Lyras, D, Lacy, DB, Wilcox, MH, Kuijper, EJ.
Clostridium difficile infection. Nat Rev Dis Primer 2016;2:16020.
3. Vardakas, KZ, Trigkidis, KK, Boukouvala, E, Falagas, ME.
Clostridium difficile infection following systemic antibiotic administration in randomised controlled trials: a systematic review and meta-analysis. Int J Antimicrob Agents 2016;48:1–10.
4. Kramer, A, Schwebke, I, Kampf, G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis 2006;6:130.
5. Sethi, AK, Al‐Nassir, WN, Nerandzic, MM, Bobulsky, GS, Donskey, CJ. Persistence of skin contamination and environmental shedding of Clostridium difficile during and after treatment of C. difficile infection. Infect Control Hosp Epidemiol 2010;31:21–27.
6. Samore, MH, Venkataraman, L, DeGirolami, PC, Arbeit, RD, Karchmer, AW. Clinical and molecular epidemiology of sporadic and clustered cases of nosocomial Clostridium difficile diarrhea. Am J Med 1996;100:32–40.
7. Weber, DJ, Rutala, WA, Miller, MB, Huslage, K, Sickbert-Bennett, E. Role of hospital surfaces in the transmission of emerging health care-associated pathogens: norovirus, Clostridium difficile, and Acinetobacter species. Am J Infect Control 2010;38:S25–S33.
8. Hospodsky, D, Yamamoto, N, Peccia, J. Accuracy, precision, and method detection limits of quantitative PCR for airborne bacteria and fungi. Appl Environ Microbiol 2010;76:7004–7012.
9. Shams, AM, Rose, LJ, Edwards, JR, et al. Assessment of the overall and multidrug-resistant organism bioburden on environmental surfaces in healthcare facilities. Infect Control Hosp Epidemiol 2016;37:1426–1432.
10. Ali, S, Muzslay, M, Wilson, P. A novel quantitative sampling technique for detection and monitoring of Clostridium difficile contamination in the clinical environment. J Clin Microbiol 2015;53:2570–2574.
11. Engelhardt, NEP, Foster, NF, Hong, S, Riley, TV, McGechie, DB. Comparison of two environmental sampling tools for the detection of Clostridium difficile spores on hard bathroom surfaces in the hospital setting. J Hosp Infect 2017;96:295–296.
12. Huslage, K, Rutala, WA, Sickbert-Bennett, E, Weber, DJ. A quantitative approach to defining “high-touch” surfaces in hospitals. Infect Control Hosp Epidemiol 2010;31:850–853.
13. Rashid, T, Vonville, H, Hasan, I, Garey, KW. Mechanisms for floor surfaces or environmental ground contamination to cause human infection: a systematic review. Epidemiol Infect 2017;145:347–357.
14. Altman, N, Krzywinski, M. Points of significance: split plot design. Nat Methods 2015;12:165–166.
15. Jones, B, Nachtsheim, CJ. Split-plot designs: what, why, and how. J Qual Technol 2009;41:340–361.
16. Ontario Agency for Health Protection and Promotion, Provincial Infectious Diseases Advisory Committee. Best Practices for Environmental Cleaning for Prevention and Control of Infections in All Health Care Settings, 2nd revision. Toronto, Canada; 2012.
17. Surface Sampling Procedures for Bacillus Anthracis Spores from Smooth, Non-Porous Surfaces. Washington, USA: The National Institute for Occupational Safety and Health; 2012.
18. Mutters, R, Nonnenmacher, C, Susin, C, Albrecht, U, Kropatsch, R, Schumacher, S. Quantitative detection of Clostridium difficile in hospital environmental samples by real-time polymerase chain reaction. J Hosp Infect 2009;71:43–48.
19. Kilic, A, Alam, MJ, Tisdel, NL, et al. Multiplex real-time PCR method for simultaneous identification and toxigenic type characterization of Clostridium difficile from stool samples. Ann Lab Med 2015;35:306.
20. Ogden, TL. Handling results below the level of detection. Ann Occup Hyg 2010;54:255–256.
21. Hidalgo, B, Goodman, M. Multivariate or multivariable regression? Am J Public Health 2013;103:39–40.
22. Guthrie, KA, Gammill, HS, Kamper-Jørgensen, M, et al. Statistical methods for unusual count data: examples from studies of microchimerism. Am J Epidemiol 2016;184:779–786.
23. Stan Development Team. rstanarm: Bayesian applied regression modeling via Stan. R package version 2·13·1. Stan website. http://mc-stan.org/. Published 2016. Accessed April 23, 2018.
24. Buggy, BP, Wilson, KH, Fekety, R. Comparison of methods for recovery of Clostridium difficile from an environmental surface. J Clin Microbiol 1983;18:348–352.
25. Nerandzic, MM, Donskey, CJ. Effective and reduced-cost modified selective medium for isolation of Clostridium difficile
. J Clin Microbiol 2009;47:397–400.
26. Buttner, MP, Cruz, P, Stetzenbach, LD, Klima-Comba, AK, Stevens, VL, Emanuel, PA. Evaluation of the biological sampling kit (BiSKit) for large-area surface sampling. Appl Environ Microbiol 2004;70:7040–7045.
27. Moore, G, Muzslay, M, Wilson, APR. The type, level, and distribution of microorganisms within the ward environment: a zonal analysis of an intensive care unit and a gastrointestinal surgical ward. Infect Control Hosp Epidemiol 2013;34:500–506.
28. Rashid, T, VonVille, HM, Hasan, I, Garey, KW. Shoe soles as a potential vector for pathogen transmission: a systematic review. J Appl Microbiol 2016;121:1223–1231.
29. Qian, J, Peccia, J, Ferro, AR. Walking-induced particle resuspension in indoor environments. Atmos Environ 2014;89:464–481.
30. Brown, K, Valenta, K, Fisman, D, Simor, A, Daneman, N. Hospital ward antibiotic prescribing and the risks of Clostridium difficile infection. JAMA Intern Med 2015;175:626–633.
31. Dubberke, ER, Reske, KA, Olsen, MA, et al. Evaluation of Clostridium difficile–associated disease pressure as a risk factor for C difficile–associated disease. Arch Intern Med 2007;167:1092–1097.
32. Tosas Auguet, O, Stabler, RA, Betley, J, et al. Frequent undetected ward-based methicillin-resistant Staphylococcus aureus transmission linked to patient sharing between hospitals. Clin Infect Dis 2018;66:840–848.
33. Weese, JS.
Clostridium difficile in food–innocent bystander or serious threat? Clin Microbiol Infect 2010;16:3–10.
34. Lawley, TD, Clare, S, Deakin, LJ, et al. Use of purified Clostridium difficile spores to facilitate evaluation of health care disinfection regimens. Appl Environ Microbiol 2010;76:6895–6900.