Skip to main content
    • Aa
    • Aa

Increasing Incidence of Sterile-Site Infections Due to Non-Multidrug-Resistant, Oxacillin-Resistant Staphylococcus aureus Among Hospitalized Patients

  • Garrett E. Schramm (a1), Jennifer A. Johnson (a2), Joshua A. Doherty (a3), Scott T. Micek (a1) and Marin H. Kollef (a2)...

The incidence of community-associated, healthcare-associated, and hospital-acquired sterile-site infections due to methicillin-re-sistant Staphylococcus aureus (MRSA) isolates and the susceptibility of the isolates to non-β-lactam antibiotics were evaluated for 549 hospitalized patients during a 3-year period. The incidence of community-associated MRSA infection increased significantly. The annual percentage of MRSA isolates from cases of healthcare-associated and hospital-acquired infection that were susceptible to 3 or more non-β-lactam antibiotics increased significantly.

Corresponding author
Barnes-Jewish Hospital, Department of Pharmacy, Mailstop 90-52-411, 216 S. Kingshighway Blvd., St. Louis, MO 63110 (
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. SK Fridkin , JC Hageman , M Morrison , et al. Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med 2005;352:14361444.

2. JS Francis , MC Doherty , U Lopatin , et al. Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. Clin Infect Dis 2005;40:100107.

3. ST Micek , M Dunne , MH Kollef . Pleuropulmonary complications of Panton-Valentine leukocidin-positive community-acquired methicillinresistant Staphylococcus aureus: importance of treatment with antimicrobials inhibiting exotoxin production. Chest 2005;128:27322738.

5. TS Naimi , KH LeDell , K Como-Sabetti , et al. Comparison of community-and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 2003;290:29762984.

6. AI Hidron , EV Kourbatova , JS Halvosa , et al. Risk factors for colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients admitted to an urban hospital: emergence of community-associated MRSA nasal carriage. Clin Infect Dis 2005;41:159166.

7. PdA Trindade , RL Pacheco , SF Costa , et al. Prevalence of SCCmec type IV in nosocomial bloodstream isolates of methicillin-resistant Staphylococcus aureus . J Clin Microbiol 2005;43:34353437.

8. RM Klevens , JR Edwards , FC Tenover , LC McDonald , T Horan , R Gaynes . Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992–2003. Clin Infect Dis 2006;42:389391.

9. PC Schreckenberger , E Ilendo , KL Ristow . Incidence of constitutive and inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci in a community and a tertiary care hospital. J Clin Microbiol 2004;42:27772779.

10. S Chavez-Bueno , B Bozdogan , K Katz , et al. Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas. An-timicrob Agents Chemother 2005;49:22832288.

11. U Seybold , EV Kourbatova , JG Johnson , et al. Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections. Clin Infect Dis 2006;42:647656.

12. L-Y Hsu , T-H Koh , K Singh , M-L Kang , A Kurup , B-H Tan . Dissemination of multisusceptible methicillin-resistant Staphylococcus aureus in Singapore. J Clin Microbiol 2005;43:29232925.

13. P-Y Donnio , L Preney , A-L Gautier-Lerestif , J-L Avril , N Lafforgue . Changes in staphylococcal cassette chromosome type and antibiotic resistance profile in methicillin-resistant Staphylococcus aureus isolates from a French hospital over an 11 year period. J Antimicrob Chemother 2004;53:808813.

14. N van der Mee-Marquet , A-S Domelier , N Girard , R Quentin , the Bloodstream Infection Study Group of the Relais d'Hygiene du C. Epidemiology and typing of Staphylococcus aureus strains isolated from bloodstream infections. J Clin Microbiol 2004;42:56505657.

15. LG Miller , F Perdreau-Remington , G Rieg , et al. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med 2005;352:14451453.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 1 *
Loading metrics...

Abstract views

Total abstract views: 22 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 23rd June 2017. This data will be updated every 24 hours.