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Klebsiella pneumoniae Carbapenemase–Producing Organisms: An Ounce of Prevention Really Is Worth a Pound of Cure

  • Arjun Srinivasan (a1) and Jean B. Patel (a1)

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Corresponding author

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Rd., MS A35, Atlanta, GA 30333 (asrinivasan@cdc.gov)

References

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1. Yigit, H., Queenan, AM, Andersen, GJ, et al. Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae . Antimicrob Agents Chemother 2001;45:11511161.
2. Queenan, AM, Bush, K. Carbapenemases: the versatile β-lactamases. Clin Microbiol Rev 2007;20:440458.
3. Rice, LB, Carias, LL, Hutton, RA, Rudin, SD, Endimiani, A, Bonomo, RA. The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae . Antimicrob Agents Chemother 2008;52:34273429.
4. Patel, G, Huprikar, S, Factor, SH, Jenkins, SG, Calfee, DP. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008;29:10991106 (in this issue).
5. Lee, K, Chong, Y, Shin, HB, Kim, YA, Yong, D, Yum, JH. Modified Hodge and EDTA-disk synergy tests to screen metallo-β-lactamase-producing strains of Pseudomonas and Acinetobacter species. Clin Microbiol Infect 2001;7:8891.
6. Leavitt, A, Navon-Venezia, S, Chmelnitsky, I, Schwaber, MJ, Carmeli, Y. Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Antimicrob Agents Chemother 2007;51:30263029.
7. Samra, Z, Ofir, O, Lishtzinsky, Y, Mador-Shapiro, L, Bishara, J. Outbreak of carbapenem-resistant Klebsiella pneumoniae producing KPC-3 in a tertiary medical centre in Israel. Int J Antimicrob Agents 2007;30:525529.
8. Stürenburg, E, Mack, D. Extended-spectrum β-lactamases: implications for the clinical microbiology laboratory, therapy, and infection control. J Infect 2003;47:273295.
9. Management of Multi-Drug Resistant Organisms in Healthcare Settings, 2006. Healthcare Infection Control Practices Advisory Committee. Available at: http://www.cdc.gov/ncidod/dhqp/pdf/ar/mdroGuideline2006.pdf. Accessed October 17, 2008.

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