Hostname: page-component-76dd75c94c-vpfzz Total loading time: 0 Render date: 2024-04-30T07:17:00.863Z Has data issue: false hasContentIssue false

Management of Healthcare Workers Exposed to Pertussis

Published online by Cambridge University Press:  02 January 2015

William A. Rutala
Affiliation:
Division of Infectious Diseases, University of North Carolina (UNC) at Chapel Hill, the Department of Hospital Epidemiology and the Department of Employee Health, UNC Hospitals, Chapel Hill, North Carolina
David J. Weber*
Affiliation:
Division of Infectious Diseases, University of North Carolina (UNC) at Chapel Hill, the Department of Hospital Epidemiology and the Department of Employee Health, UNC Hospitals, Chapel Hill, North Carolina
*
547 Burnett-Womack, CB #7030, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7030

Abstract

The epidemiology of pertussis has changed in recent years. First, pertussis in adults is far more common than previously thought. Second, in many instances, the disease in adults is atypical or asymptomatic. Third, adult pertussis occurs despite a prior history of full immunization and, indeed, in persons with a prior history of natural disease.

Large outbreaks of pertussis have occurred in healthcare facilities through failure to recognize and isolate infected infants and children, failure to recognize and treat disease in staff members, and failure to institute control measures rapidly. Appropriate use of work restriction and erythromycin prophylaxis may decrease the likelihood of institutional outbreaks

Type
Topics in Occupational Medicine
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Addiss, DG, Davis, JP, Meade, BD, et al.A pertussis outbreak in a Wisconsin nursing home.] Infect Dis 1991;164:704710.Google Scholar
2.Gilchrist, MJRBordetella. In: Balows, A, ed. Manual of Clinical Microbiology. 5th ed. Washington, DC: American Society for Microbiology; 1991:471477.Google Scholar
3.Hewlett, EL. Bordetella species. In: Mandell, GL, Douglas, RG, Bennett, JE, eds. Principles and Practices of Infectious Diseases. 3rd ed. New York, NY: Churchill Livingstone; 1990:17561762.Google Scholar
4.Centers for Disease Control and Prevention. Resurgence of pertussis-United States, 1993. MMWR 1993;42:952-953,959960.Google Scholar
5.Sutter, RW, Cochi, SL. Pertussis hospitalizations and mortality in the U.S., 19851988: evaluation of the completeness of national reporting. JAMA 1992;267:386391.Google Scholar
6.Biellik, RJ, Patriarca, PA, Mullen, JR, et al.Risk factors for community- and household-acquired pertussis during a large-scale outbreak in central Wisconsin. J Infect Dis 1988;157:11341141.Google Scholar
7.Nelson, JD. The changing epidemiology of pertussis in young infants: The role of adults as reservoirs of infection. Am J Dis Child 1978;132:371373.Google Scholar
8.Lambert, HJ. Epidemiology of a small pertussis outbreak in Kent County, Michigan. Public Health Reports 1965;80:365369.Google Scholar
9.Herwaldt, LA. Pertussis in adults: what physicians need to know. Arch Intern Med 1991;151:15101512.Google Scholar
10.Bass, JW, Stephenson, SR. The return of pertussis. Pediatr Infect Dis 1987;6:141144.Google Scholar
11.Long, SS, Welkon, CJ, Clark, JL. Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology. J Infect Dis 1990;161:480486.Google Scholar
12.Mertsola, J, Ruuskanen, O, Eerola, E, Viljanen, MK. Intrafamilial spread of pertussis. J Pediatr 1983;103:359363.Google Scholar
13.Steketee, RW, Burstyn, DG, Wassilak, SGEA comparison of laboratory and clinical methods for diagnosing pertussis in an outbreak in a facility for the developmentally disabled. J Infect Dis 1988;157:441449.Google Scholar
14.Fisher, MC, Long, SS, McGowan, KL, Kaselis, E, Smith, DG. Outbreak of pertussis in a residential facility for handicapped people. J Pediatr 1989;114:934939.Google Scholar
15.Onorato, IM. Wassilak SGE Laboratorv diagnosis of nertussis: the state of the art. Pediatr Infect Dis 1987;6:145151.Google Scholar
16.He, Q, Mertsola, J, Soini, H, Skurnik, M, Ruuskanen, O, Viljanen, MK. Comparison of polymerase chain reaction with culture and enzyme immunoassay for diagnosis of pertussis. J Clin Microbial 1993;31:642645.Google Scholar
17.Granstrom, G, Wretlind, B, Granstrom, M. Diagnostic value of clinical and bacteriological findings in pertussis. J Infect 1991;22:1726.Google Scholar
18.Zackrisson, G, Brorson, JE, Krantz, I, Trollfors, B. In-vitro sensitivity of Bordetella pertussis. J Antimicrob Chemother 1983;11:407411.Google Scholar
19.Hoppe, JE, Haug, A. Antimicrobial susceptibility of Bordetella pertussis (part 1). Infection 1988;16:126130.Google Scholar
20.Steketee, RW, Wassilak, GEAdkins, WN Jret al.Evidence for a high attack rate and efficacy of erythromycin prophylaxis in a pertussis outbreak in a facility for the developmentally disabled. J Infect Dis 1988;157:434440.Google Scholar
21.Bergquist, SO, Bemander, S, Dahnsjo, H, Sundelof, B. Erythromytin in the treatment of pertussis: a study of bacteriologic and clinical effects. Pediatr Infect Dis 1987;6:458461.Google Scholar
22.Bass, JW, Klenk, EL, Kotheimer, JB, et al.Antimicrobial treatment of pertussis. J Pediatr 1969;75:768781.Google Scholar
23.Granstrom, G, Sterner, G, Nord, CE, Granstrom, M. Use of erythromycin to prevent pertussis in newborns of mothers with pertussis. J Infect Dis 1987;155:12101214.Google Scholar
24.Sprauer, MA, Cochi, SL, Zell, ER, et al.Prevention of secondary transmission of pertussis in households with early use of erythromycin. Am J Dis Child 1992;146:177181.Google Scholar
25.Hoppe, JE, Haug, A. Treatment and prevention of pertussis by antimicrobial agents (part 2). Infection 1988;16:148151.Google Scholar
26.Grob, PR. Prophylactic erythromycin for whooping-cough contacts. Lancet 1981;1:772.Google Scholar
27.Halsey, NA, Welling, MA, Lehman, RIM. Nosocomial pertussis: a failure of erythromycin treatment and prophylaxis. Am J Dis Child 1980;134:521522.Google Scholar
28.Bass, JW. Pertussis: current status of prevention and treatment. Adiatr Infect Dis 1985;4:614619.Google Scholar
29.Tanaka, Y, Fujinaga, K, Goto, A, et al.Outbreak of pertussis in a residential facility for handicapped people. Dev Biol Stand 1991;73:329332.Google Scholar
30.Linnemann, CC JrRamundo, N, Perlstein, PH, Minton, SD, Englender, GS. Use of pertussis vaccine in an epidemic involving hospital staff. Lancet 1975;2:540543.Google Scholar
31.Kurt, TL, Yeager, AS, Guenette, S, Dunlop, S. Spread of pertussis by hospital staff. JAMA 1972;221:264267.Google Scholar
32.Valenti, WM, Pius, PH, Messner, MK. Nosocomial pertussis: possible spread by a hospital visitor. Am J Dis Child 1980;134:520521.Google Scholar
33.Centers for Disease Control. Diphtheria, tetanus, and pertussis: recommendations for vaccine use and other preventive measures: recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR 1991;40(no. RR-10):128.Google Scholar
34.Committee on Infectious Diseases. Red Book. Elk Grove Village, IL: American Academv of Pediatrics: 1991:358361.Google Scholar
35.Hoppe, JE, Eichhorn, AActivity of new macrolides against Bordetella pertussis and Bordetella parapertussis. Eur J Clin Microbial Infect Dis 1989;8:653654.Google Scholar
36.Ogura, H, Kubota, H, Nomura, I, et al.Clinical efficacy of clarithromycin in the field of pediatrics. Jpn J Antibiot 1989;42:401410.Google Scholar
37.Sekiguchi, T, Okamoto, T, Ohara, K, Nishimori, M, Kozan, S, Miyazaki, M. Clinical observations with clarithromycin in pediatrics. Jpn J Antibiot 1989;42:411419.Google Scholar
38.Tsutsui, T, Haruta, T, Kuroki, S, Ohkura, K, Kobayashi, Y. A clinical study on clarithromycin especially on its granular form for children in pediatrics. Jpn J Antibiot 1989;42:381387.Google Scholar
39.Edwards, KM, Decker, MD, Graham, BS, Mezzatesta, J, Scott, J, Hackell, J. Adult immunization with acellular pertussis vaccine. JAMA 1993;269:5356.Google Scholar
40.Mot-timer, EA. Pertussis and its prevention: a family affair. /Infect Dis 1990;161:473479.Google Scholar