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Predictors of Mortality Among Patients With Community-Onset Infection Due to Extended-Spectrum β-Lactamase-Producing Escherichia coli in Thailand

Published online by Cambridge University Press:  02 January 2015

Anucha Apisarnthanarak*
Affiliation:
Division of Infectious Diseases, Faculty of Medicine, Thammasart University Hospital, Pratumthani, Thailand
Patarachai Kiratisin
Affiliation:
Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Piyawan Saifon
Affiliation:
Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Rungrueng Kitphati
Affiliation:
Division of Science, Thai National Institute of Health, Nonthaburi, Thailand
Surang Dejsirilert
Affiliation:
Division of Science, Thai National Institute of Health, Nonthaburi, Thailand
Linda M. Mundy
Affiliation:
Saint Louis University School of Public Health, Saint Louis, Missouri
*
Division of Infectious Diseases, Faculty of Medicine, Thammasart University Hospital, Pratumthani, Thailand12120 (ananpisarn@yahoo.com)

Abstract

A matched case-control study was performed to identify predictors of mortality among patients (n = 46) with community-onset infections due to extended-spectrum β-lactamase-producing Escherichia coli in Thailand. The crude mortality rate was 30%. By multivariable analysis, community-onset bloodstream infection due to extended-spectrum β-lactamase-producing E. coli was the sole predictor of mortality (adjusted odds ratio, 41.3 [95% confidence interval, 4.3-69.4]; P = .001).

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

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References

1.Colodner, R, Rock, W, Chazan, B, et al.Risk factors for the development of extended-spectrum β-lactamase-producing bacteria in nonhospitali-zed Patients. Eur J Clin Microbiol Infect Dis 2004;23:163167.CrossRefGoogle ScholarPubMed
2.Calbo, E, Romany, V, Xercavins, M, et al.Risk factors for community-onset urinary tract infections due to Escherichia coli harboring extended-spectrum β-lactamases. J Antimicrob Chemother 2005;57:780783.Google Scholar
3.Apisarnthanarak, A, Kiratisin, P, Saifon, P, Kitphati, R, Dejsirilert, S, Mundy, LM. Clinical and molecular epidemiology of community-onset extended spectrum β-lactamase producing Escherichia coli in Thailand: a case-case-control study. Am J Infect Control 2007;35:606612.CrossRefGoogle ScholarPubMed
4.Rodriguez-Bano, J, Navarro, MD, Romero, L, et al.Bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in the CTX-M era: a new clinical challenge. Clin Infect Dis 2006;43:14071414.CrossRefGoogle Scholar
5.Dejsirilert, S, Apisarnthanarak, A, Kitphati, R, et al.The status of antimicrobial resistance in Thailand among gram-negative pathogens in bloodstream infections: NARST data, 2000-2003. In: Program and abstracts of the 9th Western Pacific Congress on Chemotherapy and Infectious Diseases (Bangkok). 2004:185 (Abstract FP-A-3).Google Scholar
6.Apisarnthanarak, A, Danchaivijitr, S, Bailey, TC, et al.Inappropriate antibiotic use in a tertiary care center in Thailand: an incidence study and review of experience in Thailand. Infect Control Hosp Epidemiol 2006;27:416420.Google Scholar
7.Garner, JS, Jarvis, WR, Emori, TG, et al.CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988;16:128140.Google Scholar
8.Kollef, MH. Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized Patients. Clin Infect Dis 2000;31(suppl 4):S131S138.Google Scholar
9.Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing: Sixteenth Informational Supplement. Wayne, PA: CLSI; 2006:M100S16.Google Scholar
10.Harris, AD, Samore, MH, Lipsitch, M, Kaye, KS, Perencevich, E, Carmeli, Y. Control-group selection importance in studies of antimicrobial resistance: examples applied to Pseudomonas aeruginosa, enterococci, and Escherichia coli. Clin Infect Dis 2002;34:15581563.CrossRefGoogle ScholarPubMed