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Prolonged Hospital Epidemic of Salmonellosis: Use of Trimethoprim-Sulfamethoxazole for Control

Published online by Cambridge University Press:  02 January 2015

Calvin C. Linnemann Jr ,
Constance G. Cannon ,
Joseph L. Staneck  and
Bonnie L. McNeely
Calvin C. Linnemann Jr*
Affiliation:
Department of Internal Medicine, and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, and the Department of Nursing, Holmes Division, University of Cincinnati Hospital, Cincinnati, Ohio
Constance G. Cannon
Affiliation:
Department of Internal Medicine, and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, and the Department of Nursing, Holmes Division, University of Cincinnati Hospital, Cincinnati, Ohio
Joseph L. Staneck
Affiliation:
Department of Internal Medicine, and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, and the Department of Nursing, Holmes Division, University of Cincinnati Hospital, Cincinnati, Ohio
Bonnie L. McNeely
Affiliation:
Department of Internal Medicine, and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, and the Department of Nursing, Holmes Division, University of Cincinnati Hospital, Cincinnati, Ohio
*
Division of Infectious Diseases, University of Cincinnati College of Medicine, Mail Location #560, Cincinnati, OH 45267
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Abstract

The occurrence of a foodborne outbreak of Salmonella drypool, an uncommon serotype, led to the recognition of hospital-acquired cases occurring over a 5-year period. In late 1981, a catered luncheon resulted in an epidemic of S. drypool, and in retrospect, cases were found to have been occurring in hospital patients from 1977 until 1981. Over the next 4 months, patients, employees, and 50% of the kitchen workers became infected, despite repeated culture surveys of the staff and removal of all infected workers. Food and environmental cultures failed to reveal the source of infection, but infected workers were observed to have multiple negative cultures over several months and then to become positive again. Closing of the kitchen for 2 weeks failed to stop the epidemic. Finally, all kitchen employees, both infected and uninfected, were treated with trimethoprim-sulfamethoxazole for 2 weeks. After treatment, no new kitchen workers became infected, although two workers who had had positive cultures earlier in the epidemic began to excrete S. drypool again, and the epidemic ended.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 6 , Issue 6 , June 1985 , pp. 221 - 225
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1985

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References

1.Schroeder, SA, Aserkoff, B, Brachman, PS: Epidemic salmonellosis in hospitals and institutions: A five-year review. N Engl J Med 1968; 279:674–678.Google Scholar
2.MacGregor, RR, Reinhardt, J: Person-to-Person spread of salmonella: A problem in hospitals? Lancet 1973; ii: 1001–1003.Google Scholar
3.Steere, AC, Craven, PJ, Hall, WJ, et al: Person-to-person spread of salmonella typhimurium after a hospital common-source outbreak. Lancet 1975; i:319–322.Google Scholar
4.Musher, DM, Rubenstein, D: Permanent carriers of nontvphosa salmonellae. Arch Intern Med 1973; 132:869–872.Google Scholar
5.Blaser, MJ, Rafuse, EM, Wells, JG, et al: An outbreak of salmonellosis involving multiple vehicles. Am J Epidemiol 1981; 114:663–670.Google Scholar
6.Riley, LW, Cohen, ML: Plasmid profiles and salmonella epidemiology. Lancet 1982; i:573.Google Scholar
7.Shaughnessy, HJ, Friewer, F, Snyder, A: Comparative efficiency of rectal swabs and fecal specimens in detecting typhoid and salmonella cases and earners. Am J Public Health 1948; 38:670–675.CrossRefGoogle Scholar
8.Clementi, KJ: Treatment of Salmonella carriers with trimethoprim-sulfamethoxazole. Can Med Assoc J 1975; 112:28S–32S.Google Scholar
9.Frisch, JM: Clinical experience with adverse reactions to trimethoprim-sulfamethoxazole. J Infect Dis 1973; 128:S607–S611.Google Scholar
10.Lawson, DH, Jick, H: Adverse reactions to co-trimoxazole in hospitalized medical patients. Am J Med Sci 1978; 275:53–57.Google Scholar