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Recombinant DNA and the major psychiatric disorders

Published online by Cambridge University Press:  13 June 2014

Michael Gill
Michael Gill*
Affiliation:
Bethlem Royal Hospital, Monks Orchard Road, Beckenham, Kent
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Abstract

The two major psychiatric disorders, schizophrenia and the major affective disorders are among the most common genetic conditions in man. The precise biochemical defects which cause these disorders are unknown. This article reviews the new recombinant DNA techniques and their application to date in attempting to locate the genes responsible for these disorders. As has been demonstrated for other genetic conditions, these techniques may help to elucidate the biochemical defects which lead to the development of the more genetic forms of these psychiatric illnesses.

Keywords

Bipolar disorderSchizophreniaRecombination, geneticLinkage, geneticRestriction Fragment Length Polymorphisms
Type
Review Articles
Information
Irish Journal of Psychological Medicine , Volume 6 , Issue 2 , September 1989 , pp. 95 - 99
Copyright
Copyright © Cambridge University Press 1989

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References

1.Slater, E and Cowie, V. The genetics of mental disorders. London: Oxford University Press, 1971.Google Scholar
2.Murray, R M, Reveley, A M and McGuffin, P. Genetic vulnerability to schizophrenia. Psychiatric Clinics of North America 1986; 9: 3–16.CrossRefGoogle ScholarPubMed
3.Gershon, E S, Bunney, W F, Leckman, J F. Van Eerdewegh, M and De Bauche, B A. The inheritance of affective disorders: a review of data of hypotheses. Behavioural Genetics 1976; 5: 227–261CrossRefGoogle Scholar
4.McGuffin, P and Katz, R. Nature, nurture and affective disorder. In: Deakin, J F W (ed). The Biology of Depression. London: Gaskell Press, The Royal College of Psychiatrists, 1986: 26–52.Google Scholar
5.Bertelsen, A, Harvald, B and Hauge, M. a Danish twin study of manic-depressive disorders. British Journal of Psychiatry. 1977; 130: 330–351CrossRefGoogle ScholarPubMed
6.Mendlewicz, J and Rainer, J D. Adoption study supporting genetic transmission in manic-depressive illness. Nature 1977; 268: 326–329.CrossRefGoogle ScholarPubMed
7.Book, J A, Welterberg, L and Modrzewska, K. Schizophrenia in a North Swedish geographical isolate. 1900-1917. Epidemiology, genetics, and biochemistry. Clinical Genetics 1978; 14: 373–394.CrossRefGoogle Scholar
8.Reich, T, Clayton, P J, and Winokur, G. Family history studies v. the genetics of mania. American Journal of Psychiatry 1969; 125: 1358–1369.CrossRefGoogle ScholarPubMed
9.O'Rourke, D H, McGuffin, P and Reich, T. Genetic analysis of manic depressive illness. American Journal of Physical Anthropology 1983; 62: 51–59.CrossRefGoogle ScholarPubMed
10.Tsuang, M T, Winokur, G and Crowe, R. Morbidity risks of schizophrenia and affective disorders among first degree relatives with schizophrenia, manic depression, and surgical conditions. British Journal of Psychiatry 1980; 137: 497–504.CrossRefGoogle ScholarPubMed
11.Heston, I L and Denney, D. Interactions between early life experience and biological factors in schizophrenia. In: Rosenthal, D and Kety, S, eds. The Transmission of Schizophrenia. Oxford, England: Pergamon Press, 1968.Google Scholar
12.Rosenthal, D, Wender, P H, Kety, S S, Schulsinger, F, Welner, J and Østengaard, L. Schizophrenic offspring reared in adoptive homes. In: Rosenthal, D and Kety, S, eds. The Transmission of Schizophrenia. Oxford, England: Pergamon Press, 1968.Google Scholar
13.Kety, S S, Rosenthal, D, Wender, P H and Schulsinger, F. The types and Prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. In: Rosenthal, D and Kety, S, eds. The Transmission of Schizophrenia. Oxford, England: Pergamon Press, 1968.Google Scholar
14.Gottesman, I I and Shields, J. Schizophrenia: The Epigenetic Puzzle Cambridge, England: Cambridge University Press, 1982.Google Scholar
15.Heston, I L. The genetics of schizophrenia and schizoid disease. Science 1970; 167: 249–256.CrossRefGoogle ScholarPubMed
16.Gottesman, I I and Shields, J. A Polygenic theory of schizpohrenia. Proceedings of the National Academcy of Sciences 1967; 58: 199–205.CrossRefGoogle Scholar
17.O'Rourke, D H, Gottensman, I I, Suarez, B K, Rice, J and Reich, T. Refutation of the single locus model in the aetiology of schizophrenia. American Journal of Human Genetics 1982; 33: 630–649.Google Scholar
18.Yates, J R W and Connor, J M. Linkage Analysis. British Journal of Hospital Medicine 1986; 36: 133–136.Google Scholar
19.Mohr, J. Estimation of Linkage between Lutheran and Lewis blood groups. Acta palhologica et microbiologica Scandinavica 1951; 29: 339–344.CrossRefGoogle ScholarPubMed
20.McKusick, V A, Mendelian inheritance in man. 9th ed. Baltimore and London: John Hopkins University Press, 1986.Google Scholar
21.Botstein, D, White, R L, Skolvick, M and David, R W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics 1980; 32: 314–331.Google ScholarPubMed
22.Smith, H O and Wilcox, K W. A restriction enzyme from Haemophilus Influenzae I. Purification and general properties. Journal of Molecular Biology 1970; 51: 379–391.CrossRefGoogle ScholarPubMed
23.Southern, E M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology 1975; 98: 503–517.CrossRefGoogle ScholarPubMed
24.Morton, N E. The detection and estimation of linkage between the genes for elliptocytosis and Rh blood type. American Journal of Human Genetics 1956; 8: 80–96.Google ScholarPubMed
25.Weatherall, D J. The new genetics and clinical practice second edition. Oxford: Oxford University Press, 1985.Google Scholar
26.Gusella, J F, Wexler, N S, Conneally, P M, et al.A polymorphic DNA marker genetically linked to Huntington's disease. Nature 1983; 306: 234–238.CrossRefGoogle ScholarPubMed
27.Murray, J M, Davies, K E, Harper, P S, Meredith, L, Mueller, C R and Williamson, R. Linkage relationship of a cloned DNA sequence on the short are of the S-chromosome to Duchenne muscular dystrophy. Nature 1982; 300: 69–71.CrossRefGoogle Scholar
28.Monaco, A P, Neve, R L, Colletti-Feener, C, Bertelson, C J, Kurnit, D M and Kunkel, L M. Isolation of candidate with DNAs for portions of the Duchenne muscular dystrophy gene. Nature 1986; 323: 646–650.CrossRefGoogle Scholar
29.Hoffman, E P, Brown, R H, and Kundel, L M. Dystrophin: The protein product of the Duchenne muscular dystrophy locus. Cell 1987; 51: 919–928.CrossRefGoogle ScholarPubMed
30.Mendlewicz, J, Linkowski, P and Wilmotte, J. Linkage between Glucose-6-phosphate dehydrogenase deficiency and manic-depressive psychosis. British Journal of Psychiatry 1980; 137: 337–342.CrossRefGoogle ScholarPubMed
31.Baron, M, Reisch, N, Hamburger, R, et al.Genetic linkage between x-chromosome markers and bipolar affective illness. Nature 1987; 326: 289–292.CrossRefGoogle ScholarPubMed
32.Menlewicz, JSimon, P, Sevy, S, et al.Polymorphic DNA marker on x-chromosome and manic-depression. Lancet 1987; 1230–2132.Google Scholar
33.Gerhard, D S, Egeland, J A, Pauls, D L, et alIs a gene for affective disorder located on the short arm of chromosome 11? American Journal of Human Genetics 1984; 36S: 35.Google Scholar
34.Egeland, J A, Gerhard, D S, Pauls, D L, et alBipolar affective disorders linked to DNA markers on chromosome 11. Nature 1987; 783–787.Google Scholar
35.Hodgkinson, S, Sherrington, R, Gurling, H M, et alMolecualar genetic evidence for heterogeneity in manic-depression. Nature 1987; 805–806.Google Scholar
36.Detera-Wadleigh, S D, Bennettini, W H, Goldin, L R, Boorman, D, Anderson, S and Gershon, E S. Close linkage of s-Harvey-nas-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees. Nature 1987; 325: 806–808.CrossRefGoogle ScholarPubMed
37.Gill, A M, McKeon, P and Humphries, P. Linkage analysis of manic-depression in an Irish family using H-ras-1 and I N S DNA markers. Journal of Medical Genetics 1988; 634–635.CrossRefGoogle Scholar
38.McGuffin, P, Festenstein, H, and Murray, R M. A family study of HLA antigens and other genetic markers in schizophrenia. Psychological Medicine 1983; 13: 31–43.CrossRefGoogle ScholarPubMed
39.Bassett, A S, McGillivray, B C, Jones, B D and Pantzer, J T. Partial trisomy chromosome 5 co-segregrating with schizophrenia. Lancet 1988; i: 799–801.CrossRefGoogle Scholar
40.Sherrington, R, Brynjolfsson, J, Petursson, H, et alSocialization of a susceptibility locus for schizophrenia on chromosome 5. Nature 1988; 336: 164–167.CrossRefGoogle ScholarPubMed
41.Kennedy, J L, Giuffra, L A, Moises, H W, et alEvidence against linkage of schizophrenia to markers on chromosome 5 in a Northern Swedish Pedigree. Nature 1988; 33: 167–170.CrossRefGoogle Scholar
42.Moss, B, Davies, K, Boni, C, Mallet, J, and Reeder, S. Linkage of tyrosine hydroxylase to four other markers on the short arm of chromosome 11. Nucleic Acids Research 1986; 14: 9927–9932.CrossRefGoogle ScholarPubMed
43.Witkowski, J A. The molecular genetics of Duchenne muscular dystrophy: the beginning of the end? Trends in Genetics 1988; 4: 27–30.CrossRefGoogle ScholarPubMed
44.Porteous, D J, van Heyningen, V. Cystic fibrosis: from linked markers to the gene. Trends in Genetics 1986; 2: 149–152.CrossRefGoogle Scholar
45.St. Clair, D, Blackwood, D, Muir, W, et alAbsence of linkage of chromosome 5q11-q13 markers to schizophrenia in Scottish families. Nature 1989; In Press.Google Scholar