No CrossRef data available.
Article contents
Intramammary treatment of clinical mastitis quarters with ceftiofur does not cause anbiotic residues in adjacent untreated quarters
Published online by Cambridge University Press: 16 February 2024
Abstract
The study was carried out in dairy cows to elucidate whether treatment of clinical mastitis quarters with Spectramast® LC (ceftiofur hydrochloride, 125 mg, Zoetis) created a reason for discarding milk from adjacent untreated healthy quarters. The antibiotic was infused once daily in the affected mammary quarter for four days. Forty-nine cows were evaluated after diagnosis of clinical mastitis in three or fewer udder quarters. In all cases, quarters that did not receive treatment had milk samples collected one day after the end of treatment. All milk samples from untreated quarters were below the maximum permissible limit for the presence of antibiotic residues after analysis with the BetaStar S Combo test. Pharmacokinetic and pharmacodynamic characteristics may explain this finding. We conclude that it is feasible to use milk from untreated quarters of animals that have been treated with Spectramast® LC. We also reiterate the need to carry out tests with other pharmacological bases, and that the results found in this experiment cannot be extrapolated to other drugs.
Dairy cattle have considerable importance in the development of the Brazilian economy, being directly linked to economic and social progress. In the first half of 2020, 12.1 billion liters of milk were produced in Brazil and in 2019, there was a new record of 25.01 billion liters produced (IBGE, 2020). This production comes from a wide variety of production systems, coming from smallholder farmers as well as from large companies that use the latest technologies available on the market. Dairy production is a complex activity. For one to obtain economical success, several aspects must be monitored. Maintaining the health of animals is a top priority, and the literature suggests that various diseases are a common challenge for dairy producers. Mastitis is the main disease that affects dairy cows, responsible for considerable economic loss and significant zootechnical and productive challenges (Ruegg, 2017). It is considered the second leading cause of cow culling in dairy herds, behind reproductive problems. Mastitis is characterized by infection of the mammary gland and may or may not occur with inflammation, generating changes in the mammary tissue and properties of the milk. It is classifield into clinical or subclinical mastitis, according to presence or absence of clinical signs, and into contagious or environmental based on the causative agent (Correa et al., 2001).
- Type
- Research Article
- Information
- Copyright
- Copyright © The Author(s), 2024. Published by Cambridge University Press on behalf of Hannah Dairy Research Foundation
References
Anika, TT, Nomam, ZA, Ferdous, MRA, Khan, SH, Mukta, M, Islam, MS, Hossain, MT and Rafiq, K (2019) Time dependent screening of antibiotic residues in milk of antibiotics treated cows. Journal of Advanced Veterinary and Animal Research 6, 516–520.CrossRefGoogle ScholarPubMed
Araújo, GD, Souza, KB, Oliveira, LAS and Ribeiro, RP (2012) Aspectos morfológicos e fisiológicos de glândulas mamárias de fêmeas bovinas – revisão de literatura. PUBVET 6, 223.CrossRefGoogle Scholar
Brown, K, Mugoh, M, Call, DR and Omulo, S (2020) Antibiotic residues and antibiotic-resistant bacteria detected in milk marketed for human consumption in Kibera, Nairobi. Plos One 15, e0233413.CrossRefGoogle ScholarPubMed
Brown, SA, Jaglan, OS and Banting, A (1991) Ceftiofur sodium: disposition, protein-blinding, metabolism and residue depletion profile in various species. Acta Veterinaria Scandinavica Supplement 87, 97–99.Google Scholar
Cardozo, LL, Thaler Neto, A, Souza, GN, Schmidt, FA, Werncke, D and Simon, EE (2015) Risk factors for the occurrence of new and chronic cases of subclinical mastitis in dairy herds in southern Brazil. Journal of Dairy Science 98, 7675–7685.CrossRefGoogle ScholarPubMed
Correa, FR, Schild, AL, Mendez, MDC and Lemos, RAA (2001) Doença de Rumantes e Equinos. Varela Editora e Livraria LTDA 2, 336–340.Google Scholar
Durel, L, Gallina, G and Pellet, T (2019) Assessment of ceftiofur residues in cow milk using commercial screening test kits. Veterinary Record Open 11.Google Scholar
Ganda, EK, Bisinotto, RS, Lima, SF, Kronauer, K, Decter, DH, Oikonomou, G, Schukken, YH and Bicalho, RC (2016) Longitudinal metagenomic profiling of bovine milk to assess the impact of intramammary treatment using a third-generation cephalosporin. Scientific Reports 6, 37565.CrossRefGoogle ScholarPubMed
Gorden, PJ, Kleinhenz, MD, Wulf, LW, Lee, CJ, Wang, C and Coetzee, JF (2016) Altered plasma pharmacokinetics of ceftiofur hydrochloride in cows affected with severe clinical mastites. Journal of Dairy Science 99, 505–514.CrossRefGoogle Scholar
Leitner, G, Zilberman, D, Papirov, E and Shefy, S (2018) Assessment of acoustic pulse therapy (APT), a non-antibiotic treatment for dairy cows with clinical and subclinical mastitis. Plos One 13, e0199195.CrossRefGoogle Scholar
Nisha, AR (2008) Antibiotic Residues – A global health hazard. Veterinary World 1, 375–377.CrossRefGoogle Scholar
Ruegg, PL (2017) A 100-year review: mastitis detection, management, and prevention. Journal of Dairy Science 100, 10381–10397.CrossRefGoogle ScholarPubMed
van Boeckel, TP, Brower, C, Gilbert, M, Bryan, TG, Levin, SA, Robinson, TP, Teillant, A and Laxminarayan, R (2015) Global trends in antimicrobial use in food animals. Proccedings of the National Academy of Science of the United States of America 112, 5649–5654.CrossRefGoogle ScholarPubMed
Varón, EF, Garcia, CC, Rodriguez, JMS and Rodriguez, CMC (2016) Pharmacokinetics (pk), pharmacodynamics (pd), and pk-pd integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-la administration in lactating goats. BMC Veterinary Research 12, 232.CrossRefGoogle Scholar
Carvalho et al. supplementary material
Carvalho et al. supplementary material
File
277.5 KB