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Breastfeeding moderates the association of maternal pre-pregnancy nutritional status with offspring body composition at 30 years

Published online by Cambridge University Press:  15 March 2024

Bernardo L. Horta Open the ORCID record for Bernardo L. Horta [Opens in a new window] ,
Kelly P. Coca ,
Mina Desai Open the ORCID record for Mina Desai [Opens in a new window] ,
Mariane S. Dias Open the ORCID record for Mariane S. Dias [Opens in a new window] ,
Manoella B. Jaccottet  and
Michael G. Ross
Bernardo L. Horta*
Affiliation:
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
Kelly P. Coca
Affiliation:
Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo, Brazil
Mina Desai
Affiliation:
Perinatal Research Laboratory, The Lundquist Institute at Harbor-UCLA Medical Center, Department of Obstetrics and Gynecology, Torrance, CA, USA Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Mariane S. Dias
Affiliation:
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
Manoella B. Jaccottet
Affiliation:
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
Michael G. Ross
Affiliation:
Perinatal Research Laboratory, The Lundquist Institute at Harbor-UCLA Medical Center, Department of Obstetrics and Gynecology, Torrance, CA, USA Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
*
Corresponding author: Bernardo L. Horta; Email: blhorta@gmail.com
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Abstract

Maternal pre-pregnancy body mass index is positively associated with offspring obesity, even at adulthood, whereas breastfeeding decreases the risk of obesity. The present study was aimed at assessing whether breastfeeding moderates the association of maternal pre-pregnancy body mass index with offspring body composition at adulthood, using data from 3439 subjects enrolled in a southern Brazilian birth cohort. At 30 years of age, maternal pre-pregnancy body mass index was positively associated with offspring prevalence of obesity, abdominal obesity, as well as body mass index and fat and lean mass index. Breastfeeding moderated the association of maternal pre-pregnancy obesity with offspring adiposity at 30 years of age. For those breastfed<6 months, body mass index was 4.13 kg/m2 (95% confidence interval: 2.98; 5.28) higher among offspring of obese mothers, in relation to offspring of normal weight mothers, whereas among those breastfed≥6 months the magnitude of the difference was small [2.95 kg/m2 (95% confidence interval: 1.17; 4.73)], p-value for interaction = 0.03. Concerning obesity, among those who had been breastfed < 6 months, the prevalence of obesity was 2.56 (95% confidence interval: 1.98; 3.31) times higher among offspring of obese mothers. On the other hand, among those who were breastfed ≥ 6 months, the prevalence of obesity was 1.82 (95% confidence interval: 1.09; 3.04) times higher among offspring of obese mothers. Therefore, among overweight mothers breastfeeding for more than 6 months should be supported, as it may mitigate the consequences of maternal overweight on offspring body composition.

Keywords

Maternal pre-pregnancy body mass indexbreastfeedingoffspring body compositioncohort
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 15 , 2024 , e3
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Copyright
© The Author(s), 2024. Published by Cambridge University Press in association with The International Society for Developmental Origins of Health and Disease (DOHaD)

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References

Godfrey, KM, Reynolds, RM, Prescott, SL, et al. Influence of maternal obesity on the long-term health of offspring. Lancet Diabetes Endocrinol. 2017; 5(1), 53–64. DOI: 10.1016/S2213-8587(16)30107-3.CrossRefGoogle ScholarPubMed
Reilly, JJ, Armstrong, J, Dorosty, AR, et al. Early life risk factors for obesity in childhood: cohort study. BMJ. 2005; 330(7504), 1357. DOI: 10.1136/bmj.38470.670903.E0.CrossRefGoogle ScholarPubMed
Eriksson, JG, Sandboge, S, Salonen, M, Kajantie, E, Osmond, C. Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki birth cohort study (HBCS). Ann Med. 2015; 47(2), 94–99. DOI: 10.3109/07853890.2015.1004360.CrossRefGoogle ScholarPubMed
da Dias, MS, Matijasevich, A, Barros, AJ, et al. Influence of maternal pre-pregnancy nutritional status on offspring anthropometric measurements and body composition in three Brazilian birth cohorts. Public Health Nutr. 2021; 24(5), 882–894. DOI: 10.1017/S1368980020004887.CrossRefGoogle Scholar
Gaillard, R, Steegers, EAP, Duijts, L, et al. Childhood cardiometabolic outcomes of maternal obesity during pregnancy. Hypertension. 2014; 63(4), 683–691. DOI: 10.1161/HYPERTENSIONAHA.113.02671.CrossRefGoogle ScholarPubMed
Pinot de Moira, A, Power, C, Li, L. Changing influences on childhood obesity: a study of 2 Generations of the 1958 British birth cohort. Am J Epidemiol. 2010; 171(12), 1289–1298. DOI: 10.1093/aje/kwq083.CrossRefGoogle ScholarPubMed
Simmonds, M, Llewellyn, A, Owen, CG, Woolacott, N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obesi Revi. 2016; 17(2), 95–107. DOI: 10.1111/obr.12334.CrossRefGoogle ScholarPubMed
Paliy, O, Piyathilake, CJ, Kozyrskyj, A, Celep, G, Marotta, F, Rastmanesh, R. Excess body weight during pregnancy and offspring obesity: potential mechanisms. Nutrition. 2014; 30(3), 245–251. DOI: 10.1016/j.nut.2013.05.011.CrossRefGoogle ScholarPubMed
Santos Ferreira, DL, Williams, DM, Kangas, AJ, et al. Association of pre-pregnancy body mass index with offspring metabolic profile: analyses of 3 European prospective birth cohorts. PLoS Med. 2017; 14(8), e1002376. DOI: 10.1371/journal.pmed.1002376.CrossRefGoogle ScholarPubMed
Sharp, GC, Lawlor, DA, Richmond, RC, et al. Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the avon longitudinal study of parents and children. Int J Epidemiol. 2015; 44(4), 1288–1304. DOI: 10.1093/ije/dyv042.CrossRefGoogle ScholarPubMed
Bond, TA, Karhunen, V, Wielscher, M, et al. Exploring the role of genetic confounding in the association between maternal and offspring body mass index: evidence from three birth cohorts. Int J Epidemiol. 2020; 49(1), 233–243. DOI: 10.1093/ije/dyz095.CrossRefGoogle ScholarPubMed
Burgess, B, Morris, KS, Faith, MS, Paluch, RA, Kong, KL. Added sugars mediate the relation between pre-pregnancy BMI and infant rapid weight gain: a preliminary study. Int J Obes. 2021; 45(12), 2570–2576. DOI: 10.1038/s41366-021-00936-w.CrossRefGoogle ScholarPubMed
Mintjens, S, Gemke, RJBJ, van Poppel, MNM, Vrijkotte, TGM, Roseboom, TJ, van Deutekom, AW. Maternal prepregnancy overweight and obesity are associated with reduced physical fitness but do not affect physical activity in childhood: the Amsterdam born children and their development study. Childhood Obesity. 2019; 15(1), 31–39. DOI: 10.1089/chi.2018.0171.CrossRefGoogle Scholar
Alves, JM, Angelo, BC, Zink, J, et al. Child physical activity as a modifier of the relationship between prenatal exposure to maternal overweight/obesity and neurocognitive outcomes in offspring. Int J Obes. 2021; 45(6), 1310–1320. DOI: 10.1038/s41366-021-00794-6.CrossRefGoogle ScholarPubMed
Zambrano, E, Nathanielsz, PW. Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies. Nutr Rev. 2013; 71, S42–S54. DOI: 10.1111/nure.12068.CrossRefGoogle ScholarPubMed
Desai, M, Ross, MG. Maternal-infant nutrition and development programming of offspring appetite and obesity. Nutr Rev. 2020; 78(Supplement_2), 25–31. DOI: 10.1093/nutrit/nuaa121.CrossRefGoogle ScholarPubMed
Katzow, MW, Messito, MJ, Mendelsohn, AL, Scott, MA, Gross, RS. Protective effect of prenatal social support on the intergenerational transmission of obesity in low-income hispanic families. Child Obes. 2023; 19(6), 382–390. DOI: 10.1089/chi.2021.0306.CrossRefGoogle ScholarPubMed
Kennelly, MA, Ainscough, K, Lindsay, KL, Cronin, M, McAuliffe, FM. 336: an antenatal lifestyle intervention in overweight and obese pregnancy improves sleep behaviour and maternal wellbeing. Am J Obstet Gynecol. 2019; 220(1), S234–S235. DOI: 10.1016/j.ajog.2018.11.357.CrossRefGoogle Scholar
Horta, BL, Rollins, N, Dias, MS, Garcez, V, Pérez-Escamilla, R. Systematic review and meta-analysis of breastfeeding and later overweight or obesity expands on previous study for World Health Organization. Acta Paediatr. 2023; 112(1), 34–41. DOI: 10.1111/apa.16460.CrossRefGoogle ScholarPubMed
Brown, A, Lee, M. Breastfeeding during the first year promotes satiety responsiveness in children aged 18-24 months. Pediatr Obes. 2012; 7(5), 382–390. DOI: 10.1111/j.2047-6310.2012.00071.x.CrossRefGoogle ScholarPubMed
Dedoussis, GVZ, Yannakoulia, M, Timpson, NJ, et al. Does a short breastfeeding period protect from FTO -induced adiposity in children? Int J Pediatr Obes. 2011; 6(2-2), e326–e335. DOI: 10.3109/17477166.2010.490269.CrossRefGoogle Scholar
Abarin, T, Yan Wu, Y, Warrington, N, Lye, S, Pennell, C, Briollais, L. The impact of breastfeeding on FTO-related BMI growth trajectories: an application to the Raine pregnancy cohort study. Int J Epidemiol. 2012; 41(6), 1650–1660. DOI: 10.1093/ije/dys171.CrossRefGoogle Scholar
Horta, BL, Victora, CG, França, GVA, et al. Breastfeeding moderates FTO related adiposity: a birth cohort study with 30 years of follow-up. Sci Rep. 2018; 8(1), 2530. DOI: 10.1038/s41598-018-20939-4.CrossRefGoogle ScholarPubMed
Church, C, Moir, L, McMurray, F, et al. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet. 2010; 42(12), 1086–1092. DOI: 10.1038/ng.713.CrossRefGoogle ScholarPubMed
Victora, CG, Barros, FC. Cohort profile: the 1982 Pelotas (Brazil) birth cohort study. Int J Epidemiol. 2006; 35(2), 237–242. DOI: 10.1093/ije/dyi290.CrossRefGoogle ScholarPubMed
Horta, BL, Gigante, DP, Goncalves, H, et al. Cohort profile update: the 1982 Pelotas (Brazil) birth cohort study. Int J Epidemiol. 2015; 44(2), 441–441e. DOI: 10.1093/ije/dyv017.CrossRefGoogle ScholarPubMed
World Health Organization. Obesity : preventing and managing the global epidemic : report of a WHO Consultation. (2000).Google Scholar
WHO & UNICEF. Indicators for assessing infant and young child feeding practices definitions and measurement methods. (2021).Google Scholar
Lean, MEJ, Han, TS, Morrison, CE. Waist circumference as a measure for indicating need for weight management. BMJ. 1995; 311(6998), 158–161. DOI: 10.1136/bmj.311.6998.158.CrossRefGoogle ScholarPubMed
Barros, AJ, Hirakata, VN. Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol. 2003; 3(1), 21. DOI: 10.1186/1471-2288-3-21.CrossRefGoogle ScholarPubMed
Horta, BL, Barros, FC, Lima, NP, et al. Maternal anthropometry: trends and inequalities in four population-based birth cohorts in Pelotas, Brazil, 1982–2015. Int J Epidemiol. 2019; 48(Supplement_1), i26–i36. DOI: 10.1093/ije/dyy278.CrossRefGoogle ScholarPubMed
Khan, SS, Ning, H, Wilkins, JT, et al. Association of body mass index with lifetime risk of cardiovascular disease and compression of morbidity. JAMA Cardiol. 2018; 3(4), 280. DOI: 10.1001/jamacardio.2018.0022.CrossRefGoogle ScholarPubMed
da Dias, MS, Matijasevich, A, Menezes, AMB, et al. Association between maternal prepregnancy body mass index with offspring cardiometabolic risk factors: analysis of three Brazilian birth cohorts. J Dev Orig Health Dis. 2022; 13(2), 161–167. DOI: 10.1017/S2040174421000179.CrossRefGoogle Scholar
Brandt, S, Moß, A, Lennerz, B, et al. Plasma insulin levels in childhood are related to maternal factors - results of the ulm birth cohort study. Pediatr Diabetes. 2014; 15(6), 453–463. DOI: 10.1111/pedi.12109.CrossRefGoogle ScholarPubMed
Hochner, H, Friedlander, Y, Calderon-Margalit, R, et al. Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors. Circulation. 2012; 125(11), 1381–1389. DOI: 10.1161/CIRCULATIONAHA.111.070060.CrossRefGoogle ScholarPubMed
Victora, CG, Horta, BL, de Mola, CL, et al. Association between breastfeeding and intelligence, educational attainment, and income at 30 years of age: a prospective birth cohort study from Brazil. Lancet Glob Health. 2015; 3(4), e199–e205. DOI: 10.1016/S2214-109X(15)70002-1.CrossRefGoogle ScholarPubMed
Zhao, Y, Wang, SF, Mu, M, Sheng, J. Birth weight and overweight/obesity in adults: a meta-analysis. Eur J Pediatr. 2012; 171(12), 1737–1746. DOI: 10.1007/s00431-012-1701-0.CrossRefGoogle ScholarPubMed
Huttly, SRA, Barros, FC, Victora, CG, Beria, JU, Vaughan, JP. Do mothers overestimate breast feeeding duration? An example of recall bias from a study in southern Brazil. Am J Epidemiol. 1990; 132(3), 572–575. DOI: 10.1093/oxfordjournals.aje.a115693.CrossRefGoogle Scholar
Brunner, J, Austin, PC. Inflation of Type I error rate in multiple regression when independent variables are measured with error. Canad J. Stat. 2009; 37(1), 33–46. DOI: 10.1002/cjs.10004.CrossRefGoogle Scholar
Gao, X, Becker, LC, Becker, DM, Starmer, JD, Province, MA. Avoiding the high Bonferroni penalty in genome-wide association studies. Genet Epidemiol. 2010; 34(1), 100–105. DOI: 10.1002/gepi.20430.CrossRefGoogle ScholarPubMed
Maessen, SE, Derraik, JGB, Binia, A, Cutfield, WS. Perspective: human milk oligosaccharides: fuel for childhood obesity prevention? Adv Nutr. 2020; 11(1), 35–40. DOI: 10.1093/advances/nmz093.CrossRefGoogle ScholarPubMed
Achike, M, Akpinar-Elci, M. The role of maternal prepregnancy body mass index in breastfeeding outcomes: a systematic review. Breastfeedi Med. 2021; 16(9), 678–686. DOI: 10.1089/bfm.2020.0376.CrossRefGoogle ScholarPubMed