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Efficacy of various anthelmintics against third-stage larvae of Ancylostoma caninum in the brain of mice

Published online by Cambridge University Press:  05 June 2009

G. M. Bhopale  and
B. S. Bhatnagar
G. M. Bhopale
Affiliation:
Department of Zoology, Madhav Science College, Vikram University, Ujjain, 456 010, India
B. S. Bhatnagar
Affiliation:
Department of Zoology, Madhav Science College, Vikram University, Ujjain, 456 010, India
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Abstract

In an experimental larval infection of Ancylostoma caninum in mice, the efficacy of various anthelmintics against the larvae migrated and established in the brain is reported for the first time. Albendazole and flubendazole were the most effective drugs. Thiabendazole, benacil, phenacizole, oxfendazole and mebendazole showed significant larvicidal activity. Tetramisole, levamisole, fenbendazole, Sch 18099, pyrantel pamoate, morantel tartrate and oxantel pamoate did not show any significant activity even at relatively high dose levels.

Keywords

Ancylostoma caninummouseanthelminticsefficacy
Type
Research Papers
Information
Journal of Helminthology , Volume 62 , Issue 1 , March 1988 , pp. 40 - 44
Copyright
Copyright © Cambridge University Press 1988

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