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Expression of tenascin in bile duct cancer of hamster liver by combined treatment of dimethylnitrosamine with Opisthorchis viverrini infections

Published online by Cambridge University Press:  12 April 2024

P. Sithithaworn ,
K. Ando ,
W. Limviroj ,
S. Tesana ,
C. Pairojkul ,
W. Yutanawiboonchai ,
Y. Chinzei ,
T. Yoshida  and
T. Sakakura
P. Sithithaworn*
Affiliation:
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
K. Ando*
Affiliation:
Department of Medical Zoology, School of Medicine, Mie University, Tsu 514-0001, Japan.
W. Limviroj
Affiliation:
Department of Medical Zoology, School of Medicine, Mie University, Tsu 514-0001, Japan.
S. Tesana
Affiliation:
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
C. Pairojkul
Affiliation:
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
W. Yutanawiboonchai
Affiliation:
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Y. Chinzei
Affiliation:
Department of Medical Zoology, School of Medicine, Mie University, Tsu 514-0001, Japan.
T. Yoshida
Affiliation:
Department of Pathology, School of Medicine, Mie University, Tsu 514-0001, Japan.
T. Sakakura
Affiliation:
Department of Pathology, School of Medicine, Mie University, Tsu 514-0001, Japan.
*
*Author for correspondence Fax: + 81 59 231 5215 E-mail: ando@doc.medic.mie-u.ac.jp
*Author for correspondence Fax: + 81 59 231 5215 E-mail: ando@doc.medic.mie-u.ac.jp
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Abstract

Tenascin is an extracellular matrix glycoprotein known to be an essential factor for the modulation of reciprocal interactions between the epithelium and mesenchyme during embryogenesis and tumourigenesis. The interactions between the expression of tenascin in the liver of Syrian golden hamster and the development of bile duct cancer in an Opisthorchis viverrini-associated cholangiocarcinoma model were investigated. The tenascin was expressed in connective tissues surrounding the dilated ducts, ductal rims and the stroma of cancers, and strongly in the stroma flame of necrotic cancer nodules. The mRNA signal for tenascin was also recognized in the stroma cells. The potential roles of tenascin as prognostic tumour markers are discussed.

Type
Review Article
Information
Journal of Helminthology , Volume 76 , Issue 3 , September 2002 , pp. 261 - 268
Copyright
Copyright © Cambridge University Press 2002

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References

Bhamarapravati, N., Thamavit, W. & Vajrasthira, S. (1978) Liver changes in hamsters infected with a liver fluke of man, Opisthorchis viverrini . American Journal of Tropical Medicine and Hygiene 27, 787–794.CrossRefGoogle ScholarPubMed
Chiquet-Ehrismann, R., Mackie, E.J., Pearson, A.C. & Sakakura, T. (1986) Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogensis. Cell 47, 131–139.CrossRefGoogle Scholar
Ekblom, P. & Aufderheide, E. (1989) Stimulation of tenascin expression in mesenchyme by epithelial-mesenchyme interactions. International Journal of Developmental Biology 33, 71–79.Google Scholar
Erickson, H.P. & Bourdon, M.A. (1989) Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors. Annual Review of Cell Biology 5, 71–92.CrossRefGoogle ScholarPubMed
Haswell-Elkins, M.R., Sithithaworn, P. & Elkins, D. (1992) Opisthorchis viverrini and cholangiocarcinoma in northeast Thailand. Parasitology Today 8, 86–89.CrossRefGoogle ScholarPubMed
Ishihara, A., Yoshida, T., Tamaki, H. & Sakakura, T. (1995) Tenascin expression in cancer cells and stroma of human breast cancer and its prognostic significance. Clinical Cancer Research 1, 1035–1041.Google ScholarPubMed
Isseroff, H., Sawma, J.T. & Reino, D. (1977) Fascioliasis: role of proline in bile duct hyperplasia. Science 198, 1157–1159.CrossRefGoogle ScholarPubMed
Jongsuksuntigul, P. & Imsomboon, T. (1997) The impact of a decade long opisthorchiasis control program in northeastern Thailand. Southeast Asian Journal of Tropical Medicine and Public Health 28, 551–557.Google ScholarPubMed
Kalembeyi, I., Yoshida, T., Iriyama, K. & Sakakura, T. (1997) Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study. International Journal of Developmental Biology 41, 569–573.Google Scholar
Mackie, E.J., Chiquet-Ehrismann, R., Pearson, C.A., Inaguma, Y., Taya, K., Kawarada, Y. & Sakakura, T. (1987) Tenascin is a stromal marker for epithelial malignancy in the mammary gland. Proceedings of the National Academy of Sciences of the United States of America 84, 4621–4625.CrossRefGoogle ScholarPubMed
Mackie, E.J., Halfter, W. & Liverani, D. (1988) Induction of tenascin in healing wounds. Journal of Cell Biology 107, 2757–2767.CrossRefGoogle ScholarPubMed
Preuksaraj, S. (1984) Public health aspects of opisthorchis in Thailand. Aizneimittlforschung 34, 1119–1120.Google Scholar
Riedl, S., Bodenmuller, H., Hinz, U., Holle, R., Moller, P., Schlag, P., Herfarth, C. & Faissner, A. (1995) Significance of tenascin serum level as tumor maker in primary colorectal carcinoma. Internal Journal of Cancer 64, 65–69.CrossRefGoogle Scholar
Saga, Y., Tsukamoto, T., Jing, N., Kusakabe, M. & Sakakura, T. (1991) Murine tenascin: cDNA cloning, structure and temporal expression of isoforms. Gene 104, 177–185.CrossRefGoogle ScholarPubMed
Sakakura, T. (1995) Role of tenascin in cancer development. pp. 101–129 in Adany, R., (Ed.) Tumor matrix biology. Boca Raton, Florida, CRC Press.Google Scholar
Srivatanakul, P., Sontipong, S., Chotiwan, P. & Parkin, D.M. (1988) Liver cancer in Thailand: temporal and geographic variations. Journal of Gastroenterology and Hepatology 3, 413–420.CrossRefGoogle Scholar
Tesana, S., Takahashi, Y., Sithithaworn, P., Ando, K., Sakakura, T., Yutanawiboonchai, W., Pairojkul, C. & Ruangjirachuporn, W. (2000) Ultrastructural and immunohistochemical analysis of cholangiocarcinoma in immunized Syrian golden hamsters infected with Opisthorchis viverrini and administered with dimethylnitrosamine. Parasitology International 49, 239–251.CrossRefGoogle ScholarPubMed
Thamavit, W., Bhamarapravati, N., Sahaphong, S., Vajrasthira, S. & Angskubhakorn, S. (1978) Effects of dimethylnitrosamine on induction of cholangiocarcinoma in Opisthorchis viverrini-infected Syrian golden hamsters. Cancer Research 38, 4634–4639.Google ScholarPubMed
Thamavit, W., Kongkanuntn, R., Tiwawech, D. & Moore, M.A. (1987) Level of Opisthorchis infestation and carcinogen dose-dependence of cholangiocarcinoma induction in Syrian golden hamsters. Virchows Archiv B, Cell Pathology Including Molecular Pathology 54, 52–58.CrossRefGoogle ScholarPubMed
Thamavit, W., Pairojkul, C., Tiwawech, D., Itoh, M., Shirai, T. & Ito, N. (1993) Promotion of cholangiocarcinogensis in the hamster liver by bile duct ligation after dimethylnitrosamine initiation. Carcinogenesis 14, 2415–2417.CrossRefGoogle ScholarPubMed
Tsukamoto, T., Kusakabe, M. & Saga, Y. (1991) In situ hybridization with non-radioactive digoxigenin-11-UTP-labeled cRNA probes: localization of developmentally regulated mouse tenascin mRNAs. International Journal of Developmental Biology 35, 25–32.Google ScholarPubMed
Vatanasapt, V., Uttravichien, T., Mairiang, E., Pairojkul, C., Chartbanchachai, W. & Haswell-Elkins, M. (1990) Cholangiocarcinoma in north-east Thailand. Lancet 335, 116–117.CrossRefGoogle ScholarPubMed
Yamada, S., Ichida, T., Matsuda, Y., Miyazaki, Y., Hatano, T., Hata, K., Asakura, H., Hirota, N., Geerts, A. & Wisse, E. (1992) Tenascin expression in human chronic liver disease and in hepatocellular carcinoma. Liver 12, 10–16.CrossRefGoogle ScholarPubMed