Hostname: page-component-848d4c4894-wzw2p Total loading time: 0 Render date: 2024-04-30T17:11:55.042Z Has data issue: false hasContentIssue false
  • English
  • Français

On the Early Stages of Fasciola hepatica Penetrating into the Liver of an Experimental Host, the Mouse: a Histological Picture

Published online by Cambridge University Press:  05 June 2009

Ben Dawes
Ben Dawes
Affiliation:
King's College, University of London
Get access Rights & Permissions [Opens in a new window]

Extract

1. Excystment of the metacercariae of Fasciola hepatica by perforation of the inner cyst was witnessed, but the factors which control activation of the larva remain undetermined.

2. Excystment occurred in two instances when cysts were administered to mice by intra-peritoneal injections, active young flukes being recovered.

3. Excystment occurred when cysts were administered to one week old chicks and free flukes were recovered from the abdominal cavity in three instances, but liver lesions were not observed.

4. By means of photomicrographs an attempt has been made to demonstrate that young flukes feed primarily on hepatic cells and that they show a preference for this diet. Blood is inevitably included in the diet of young flukes, but it is claimed that these are not truly blood feeders.

5. Young flukes recovered from the liver of the mouse range in length from about 0·3 mm. at 3–4 days to 4·85 mm. at 28 days from the time cysts were administered (per os). This accords fairly well with data obtained by Sinitsin and by Schumacher in respect of flukes from rabbits and guineapigs respectively.

Type
Research Article
Information
Journal of Helminthology , Volume 35 , supplement S1 , April 1961 , pp. 41 - 52
Copyright
Copyright © Cambridge University Press 1961

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Hughes, D. L., 1969.—“Chemotherapy of experimental Fasciola hepatica infections.” Ph.D. Thesis, University of London.Google Scholar
Lutz, A., 1893.—“Weiteres zur Lebensgeschichte des Distoma hepaticum.” Zbl. Bakt., 13, 320–328. (W.L. 23684.)Google Scholar
Schumacher, W., 1938.—“Untersuchungen über den Wanderungsweg und die Entwicklung von Fasciola hepatica L. im Endwirt.” Z. Parasitenk., 10, 608–643. (W.L. 23536b.)CrossRefGoogle Scholar
Schumacher, W., 1956.—“Untersuchungen über das Eindringen der Jugendformen von Fasciola hepatica L. in die Leber des Endwirts.” Ibidem, 17, 276–281.Google Scholar
Shaw, J. N., 1932.—“Studies of the liver fluke (Fasciola hepatica).” J. Amer. vet. Ass., 81, N.S. 34, 76–82. (W.L. 11022.)Google Scholar
Shirai, M., 1927.—“The biological observation on the cysts of Fasciola hepatica and the route of migration of young worms in the final host.” Sci. Rep. G. Inst. infect. Dis. Tokyo Univ., 6, 511–523. (W.L. 19989h.)Google Scholar
Sinitsin, D., 1914.—“Neue Tatsachen über die Biologie der Fasciola hepatica L.” Zbl. Bakt., 74, 280–285. (W.L. 23684.)Google Scholar
Susuki, S., 1931.—“Researches into the life-history of Fasciola hepatica and its distribution in Formosa, especially on determination of the first intermediate host and some experiments with larvae freed from their cysts artificially.” Taiwan Igakkai Zasshi, 80, 97–102 (English summary); 1418–1469 (Chinese account). (W.L. 11337.)Google Scholar
Taylor, E. L. and Parfitt, J. W., 1957.—“Mouse test for the infectivity of metacercariae with particular reference to metacercariae in snail faeces.” Trans. Amer. micr. Soc., 76, 327–328. (W.L. 21400.)Google Scholar
Vogel, H., 1934.—“Der Entwicklungszyklus von Opisthorchis felineus (Riv.) nebst Bemerkungen über die Systematik und Epidemiologie.” Zoologica, Stuttgart, 33, 1–103. (W.L. 23820.)Google Scholar