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Regulation of toxocariasis in mice selectively reared for high and low immune responses to Nematospiroides dubius

Published online by Cambridge University Press:  18 November 2009

P. J. Brindley ,
Paul Prociv ,
Catherine A. Creevey  and
I. J. East
P. J. Brindley
Affiliation:
Department of Parasitology, University of Queensland, St. Lucia 4067, Australia
Paul Prociv
Affiliation:
Department of Parasitology, University of Queensland, St. Lucia 4067, Australia
Catherine A. Creevey
Affiliation:
Department of Parasitology, University of Queensland, St. Lucia 4067, Australia
I. J. East
Affiliation:
Department of Parasitology, University of Queensland, St. Lucia 4067, Australia Long Pocket Laboratories, C.S.I.R.O. Division of Tropical Animal Science, Private Mail flag No. 3, Indooroopilly 4068, Australia
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Abstract

Test mice have been selectively reared for high (H) or low (L) immune responses to Nematospiroides dubius. After secondary infection with N. dubius, the L mice voided ten times as many eggs in their faeces as the II mice, and at necropsy, 71% versus 20% of the inoculum of N. dubius were recovered as adult worms from the L and II mice respectively. Furthermore, N. dubius were more fecund in the L than in H mice. High or low immune responsiveness was not restricted to N. dubius infection in these mice but was also observed during Toxocara canis infection. The migration of T canis larvae from gut via the liver to skeletal muscle and CNS was inhibited in H versus L mice. Many more larvae were recovered from the livers of II compared with L mice which was indicative of greater immunity in the H mice. The protective immune response in H compared with L mice to both N. dubius and T canis included pronounced cosinophilia and elevated antiparasite antibody titres.

Type
Research Article
Information
Journal of Helminthology , Volume 59 , Issue 2 , June 1985 , pp. 157 - 166
Copyright
Copyright © Cambridge University Press 1985

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References

REFERENCES

Behnke, J. M. & Parish, H. A. (1979) Expulsion of Nematospiroides dubius from the intestine of mice treated with immune serum. Parasite Immunology, 1, 13–26.CrossRefGoogle Scholar
Biozzi, G., Mouton, D., Santanna, O. A., Passos, H. C., Gennari, M., Reis, M. H., Ferreira, V. C. A., Heumann, A. M., Bouthillier, Y., Ibanez, O. M., Stiffel, C. & Siqueira, M. (1979) Genetics of immunoresponsiveness to natural antigens in the mouse. Current Topics in Microbiology and Immunology, 85, 33–98.Google Scholar
Biozzi, G., Stiffel, C., Mouton, D. & Bouthillier, Y. (1975). In: Immunogenetics and Immunodeficiency (Editor, Benacerraf, B.) p.179. Medical and Technical Publications, Lancaster, USA.CrossRefGoogle Scholar
Blum, K. & Cioli, D. (1978) Paradoxical behaviour of Biozzi high and low responder mice upon infection with Schistosoma mansoni. European Journal of Immunology, 8, 52–56.CrossRefGoogle Scholar
Brindley, P. J., & Dobson, C. (1982) Nematospiroides dubius in mice selected for liability to infection: modification of parasite biology through host selection. International Journal for Parasitology, 12, 573–578.CrossRefGoogle Scholar
Burren, C. H. (1968) Experimental toxocariasis. I. Some observations on the histopathology of the migration of Toxocara canis larvae in the mouse. Zeitschrift für parasitenkunde, 30, 152–161.CrossRefGoogle Scholar
Butterworth, A. E. (1977) The cosinophil and its role in immunity to helminth infection. Current Topics in Microbiology and Immunology, 77, 127–168.CrossRefGoogle Scholar
Claas, F. H. J. & Deelder, A. M. (1979) H-2 linked immune response to murine experimental Schistosoma mansoni infections. Journal of Immunogenetics, 6, 167–175.CrossRefGoogle Scholar
Cypess, R. H. (1972) Blood cell count changes associated with immunity to Nematospiroides dubius. Journal of Parasitology, 58, 563–566.CrossRefGoogle Scholar
Dineen, J. K. & Windon, R. G. (1980) The effect of sire selection on the response of lambs with irradiated Trichostrongylus colubriformis larvae. International Journal for Parasitology, 10, 249–252.CrossRefGoogle Scholar
Dobson, C. (1982) Passive transfer of immunity with scrum in mice infected with Nematospiroides dubius: Influence of quality and quantity of immune scrum. International Journal for Parasitology, 12, 207–213.CrossRefGoogle Scholar
Dobson, C. & Owen, M. E. (1977) Influence of serial passage on the infectivity and immunogenicity of Nematospiroides dubius in mice. International Journal of Parasitology, 7, 463–466.CrossRefGoogle Scholar
East, I. J., Hurrell, J. G. R., Todd, P. E. E. & Leach, S. J. (1982) Antigenic specificity of monoclonal antibodies to human myoglobin. Journal of Biological Chemistry, 257, 3199–3202.CrossRefGoogle Scholar
Hurley, J. C. & Vadas, M. (1983) Eosinophilia and acquisition of resistance to Nematospiroides dubius in mice sensitized with adult worms. Australian Journal of Experimental Biology and Medical Science,61, 1–9.CrossRefGoogle Scholar
Izzat, N. N. & Olson, L. J. (1970) Resistance of mice to Toxocara canis: effect of prechallenge infections and injections of worm extracts. Canadian Journal of Zoology, 48, 1063–1066.CrossRefGoogle Scholar
Jenkins, D. C. & Carrington, T. S. (1981) Nematospiroides dubius: the course of primary, secondary and tertiary infections in high and low responder Biozzi mice. Parasitology, 82, 311–318.CrossRefGoogle Scholar
Jones, C. E. & Rubin, R. (1974) Nematospiroides dubius: mechanisms of host immunity. I. Parasite counts, histopathology and scrum transfer involving orally or sub-cutaneously sensitized mice. Experimental Parasitology, 35, 434–452.CrossRefGoogle Scholar
Kay, A. H. (1976) Functions of the cosinophil lcucocytc. British Journal of Haematology, 33, 313–318.CrossRefGoogle Scholar
Kayes, S. G. & Oakes, J. A. (1978) Development of the granulomatous response in murine toxocariasis. Americasn Journal of Pathology, 93, 277–294.Google Scholar
Knopf, P. M. & Cioli, D. (1976) Schistosoma mansoni: induction of resistance to cercarial challenge by intra-mesenteric vein injection of live or fixed adult schistosomcs. Zeitschrift fü Immunitats forschung, Experimentelle and Klinische Immunologie, 152, 94–95.Google Scholar
Lee, H. F. (1960) Effects of superinfection on the behavior of Toxocara canis larvae in mice. Journal of Parasitology, 46, 583–588.CrossRefGoogle Scholar
Mclaren, D. J.(1982) Role of granulocytes in immune defences against parasites. In: Immune Reactions to Parasites (Editor, Frank, W) pp. 57–74. Gustav Fischer Verlag.: Stuttgart.Google Scholar
Misra, A., Visen, P. K. S. & Katiyar, J. C. (1981) Comparative efficacy of standard hookworm drugs against various test nematodes. Journal of Helminthology, 55, 273–278.CrossRefGoogle Scholar
Olson, L. J. (1962) Organ distribution of Toxocara canis larvae in normal mice and in mice previously infected with Toxocara, Ascaris or Trichinella. Texas Reports on Biology and Medicine, 20, 652–657.Google Scholar
Oshima, T. (1961) Standardization of techniques for infecting mice with Toxocara canis and observations on the normal migration routes of the larvae. Journal of Parasitology, 47, 652–656.CrossRefGoogle Scholar
Perrudet-Badoux, A., Binagih, R. A., Boussac-Aron, Y. (1978) Trichinella spiralis infection in mice: mechanism of the resistance in animals genetically selected for high and low antibody production. Immunology, 35, 519–522.Google Scholar
Prowse, S. J., ey, P. L. & Jenkins, C. R. (1978) Immunity to Nematospiroides dubius: cell and immunological changes associated with the onset of immunity in mice. Australian Journal of Experimental Biology and Medical Science, 56, 237–246.CrossRefGoogle Scholar
Roberts, F. H. S. & O'Sullivan, P. J. (1950) Methods for egg counts and larval cultures for strongyles infecting the gastrointestinal tract of cattle. Australian Journal of Agricultural Research, 1, 99–102.CrossRefGoogle Scholar
Russell, E. S. & Bernstein, S. E. (1966) Blood and blood formation. In: Biology of the Laboratory Mouse (Editor, Green, E. L.) pp. 351–372. McGraw-Hill Book Company: New York.Google Scholar
Sitepu, P. & Dobson, C. (1982) Genetic control of resistance to infection with Nematospiroides dubius in mice: selection of high- and low-immune response populations of mice. Parasitology, 85, 73–84.CrossRefGoogle Scholar
Snedecor, G. W. & Cochran, W. G. (1968) Statistical Methods 6th Ed. Ames: The Iowa State University Press.Google Scholar
Sprent, J. F. A. (1952) On the migratory behaviour of the larvae of various Ascaris species in white mice. I. Distribution of larvae in tissues. Journal of Infectious Diseases, 90, 165–176.CrossRefGoogle Scholar
Sprent, J. F. A. & Chen, H. H. (1949) Immunological studies in mice infected with the larvae of Ascaris lumbricoides. I. Criteria of immunity and immunizing effect of isolated worm tissues. Journal of Infectious Diseases, 84, 111–124.CrossRefGoogle Scholar