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Vaccination of sheep and cattle against haemonchosis

Published online by Cambridge University Press:  20 April 2015

C.C. Bassetto  and
A.F.T. Amarante
C.C. Bassetto
Affiliation:
UNESP – Universidade Estadual Paulista, Departamento de Parasitologia, Instituto de Biociências, CEP: 18618-970, Botucatu, São Paulo, Brazil
A.F.T. Amarante*
Affiliation:
UNESP – Universidade Estadual Paulista, Departamento de Parasitologia, Instituto de Biociências, CEP: 18618-970, Botucatu, São Paulo, Brazil
*
*E-mail: amarante@ibb.unesp.br
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Abstract

Vaccines against gastrointestinal nematodes are one potential option for the control of parasitic gastroenteritis in ruminants. Excretory/secretory (E/S) and hidden antigens are being studied as candidates for vaccines against Haemonchus spp., which is a major parasite in cattle and small ruminants that are raised in warm climates. Protection has been observed after vaccination with some E/S proteases, particularly cysteine proteases and with some glycans that are abundant on the surfaces and in the secretory products of helminths. However, the most promising results are being obtained with glycoprotein antigens extracted from the microvillar surfaces of the Haemonchus contortus intestinal cells. These antigens are called ‘hidden′ because they are not exposed to the host's immune system during infection. Thus far, recombinant forms of these antigens have not been usefully protective. However, because only 5 μg of antigen is required per dose, production of a native antigen vaccine from adult parasites has been found to be practical and commercially viable. Trials indicate that a vaccine made from one particular isolate will cross-protect against geographically distant isolates.

Type
Review Articles
Information
Journal of Helminthology , Volume 89 , Issue 5 , September 2015 , pp. 517 - 525
Copyright
Copyright © Cambridge University Press 2015 

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