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AQP1, AQP5, Bcl-2 and p16 in pharyngeal squamous cell carcinoma

Published online by Cambridge University Press:  15 June 2015

G F Lehnerdt ,
H S Bachmann ,
M Adamzik ,
A Panic ,
E Köksal ,
P Weller ,
S Lang ,
K W Schmid ,
W Siffert  and
A Bankfalvi
G F Lehnerdt*
Affiliation:
Department for Oto-Rhino-Laryngology, Head and Neck Surgery, St Anna Clinic, Teaching Hospital of the University of Dusseldorf Medical School, Wuppertal, Germany
H S Bachmann
Affiliation:
Institute of Pharmacogenetics, University Hospital Essen, University of Duisburg-Essen, Germany
M Adamzik
Affiliation:
Department of Anesthesiology, University Hospital Essen, University of Duisburg-Essen, Germany
A Panic
Affiliation:
Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Germany
E Köksal
Affiliation:
Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Germany
P Weller
Affiliation:
Department of Oto-Rhino-Laryngology, University Hospital Essen, University of Duisburg-Essen, Germany
S Lang
Affiliation:
Department of Oto-Rhino-Laryngology, University Hospital Essen, University of Duisburg-Essen, Germany
K W Schmid
Affiliation:
Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Germany
W Siffert
Affiliation:
Institute of Pharmacogenetics, University Hospital Essen, University of Duisburg-Essen, Germany
A Bankfalvi
Affiliation:
Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Germany
*
Address for correspondence: Prof Goetz F Lehnerdt, Department for Oto-Rhino-Laryngology, Head and Neck Surgery, St Anna Clinic, Teaching Hospital of the University of Dusseldorf Medical School, Vogelsangstrasse 106, 42109 Wuppertal, Germany Fax: +49-202-299-3911 E-mail: goetz.lehnerdt@cellitinnen.de
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Abstract

Objective:

This study aimed to link expression patterns of AQP1, AQP5, Bcl-2 and p16 to clinicopathological characteristics of oro-hypopharyngeal squamous cell carcinomas.

Methods:

Immunohistochemical expression of AQP1, AQP5, Bcl-2 and p16 was investigated in 107 consecutive oro-hypopharyngeal squamous cell carcinoma cases. Molecular interrelationship and correlations with clinicopathological parameters and survival were computed.

Results:

AQP1 was expressed exclusively by a subgroup of basaloid-like squamous cell carcinomas. AQP5 was detected in 25.2 per cent of the samples, showing significant association with the absence of p16 and Bcl-2 (p = 0.018; p = 0.010). In multivariate analysis, overexpression of p16 was significantly correlated with favourable overall survival (p = 0.014).

Conclusion:

AQP5 defined a subset of patients with Bcl-2-negative and p16-negative tumours with a poor clinical outcome. AQP1 was found to be a marker of a subgroup of aggressive basaloid-like squamous cell carcinomas. These findings suggest that AQP1 and AQP5 are interesting candidates for further studies on risk group classification and personalised treatment of oro-hypopharyngeal squamous cell carcinomas.

Keywords

Aquaporin 1Aquaporin 5Bcl2-Antagonist Of Cell Death ProteinP16 Protein, HumanSquamous Cell Carcinoma Of The Head And Neck
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 6 , June 2015 , pp. 580 - 586
Copyright
Copyright © JLO (1984) Limited 2015 

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