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The effect of OK-432 (Picibanil) injection on the histopathology of nasal turbinate

Published online by Cambridge University Press:  12 October 2015

S Sengul
Department of Otorhinolaryngology, Government Hospital, Karabük, Turkey
İ Kaygusuz*
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
M M Akin
Department of Pathology, Medical Faculty, Firat University, Elazig, Turkey
Ş Yalcin
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
T Karlidag
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
E Keles
Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
İ Arslan
Department of Otorhinolaryngology, Government Hospital, Bingöl, Turkey
Address for correspondence: Prof. İ Kaygusuz, Department of Otorhinolaryngology, Firat UniversityMedical Faculty, 23200 Elazig, Turkey Fax: +90 424 238 80 96 E-mail:



This study aimed to assess the histopathological effect of OK-432 (Picibanil) on rabbit nasal turbinates.


A total of 21 rabbits were divided into 3 treatment groups and various parts of both nasal turbinates were injected with 0.5 ml OK-432, 0.2 ml OK-432 or 0.6 ml saline (control). Bilateral nasal turbinates were later excised and studied under light microscopy to assess any histopathological changes.


Animals in the 0.2 ml and 0.5 ml OK-432 groups exhibited mild ciliary loss, goblet cell loss and epithelial damage, and a marked increase in inflammatory cell infiltration, submucosal vascularisation and fibrosis. There was a significant difference in histopathological changes between the two OK-432 treated groups. In addition, each OK-432 treated group had significantly more inflammatory cell infiltration, increased submucosal vascularisation and fibrosis compared with controls.


The marked fibrosis observed in OK-432-injected turbinates may be responsible for a reduction in turbinate size.

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Copyright © JLO (1984) Limited 2015 

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Presented as an oral poster at the 36th Turkish National Otorhinolaryngology Head and Neck Surgery Congress, 5–9 November, 2014. Antalya, Turkey


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