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Epstein–Barr virus-associated smooth muscle tumour mimicking bilateral vocal process granuloma

Published online by Cambridge University Press:  20 April 2007

E C Gan ,
D P C Lau  and
K L Chuah
E C Gan*
Affiliation:
Department of Otolaryngology, Singapore General Hospital, Singapore
D P C Lau
Affiliation:
Department of Otolaryngology, Singapore General Hospital, Singapore
K L Chuah
Affiliation:
Visiting Consultant, Department of Pathology, Singapore General Hospital, Singapore
*
Address for correspondence: Dr Eng Cern Gan, Department of Otolaryngology, Singapore General Hospital, Outram Road, Singapore169608. Fax: 6226 2079 E-mail: ecgan@hotmail.com
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Abstract

A case is presented of a 36-year-old Chinese woman with a renal transplant for end-stage renal failure due to Goodpasture's syndrome. She presented with a year's history of throat discomfort and acid regurgitation into her throat. Videolaryngoscopy revealed bilateral vocal process granuloma, presumed to be due to gastroesophageal reflux. A four-week course of high dose omeprazole was prescribed. On follow up a month later, the granulomas had enlarged, and laser excision was undertaken. Histological and immunohistochemical staining was consistent with Epstein–Barr virus-associated smooth muscle tumour. This is believed to be the first reported case in the English literature of such a tumour affecting the vocal process. The aim of this paper is to present the pathogenesis, clinical behaviour and treatment of Epstein–Barr virus-associated smooth muscle tumour, and to review the literature concerning the differential diagnosis of polypoid vocal process lesions.

Keywords

Epstein Barr virussmooth muscle tumourlarynx immunocompromisedgranulomasvocal process
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 1 , January 2008 , pp. 100 - 104
Copyright
Copyright © JLO (1984) Limited 2007

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