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Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome

Published online by Cambridge University Press:  03 August 2015

A Yenigun*
Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
H Karamanli
Department of Respiratory Medicine, Faculty of Medicine, Mevlana University, Konya, Turkey
Address for correspondence: Dr Alper Yenigun, Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı Vatan Caddesi, 34093 Fatih/İstanbul, Turkey Fax: +90 (212) 453 18 70 E-mail:



To investigate the neutrophil-to-lymphocyte ratio and sleep apnoea severity relationship.


Patients (n = 178) were assigned to five groups according to apnoea–hypopnea indices and continuous positive airway pressure use. White blood cell, neutrophil, lymphocyte and neutrophil-to-lymphocyte ratio values were compared for each group.


The neutrophil-to-lymphocyte ratio values of severe obstructive sleep apnoea syndrome patients (group 4) were significantly higher than those of: control patients (group 1), mild obstructive sleep apnoea syndrome patients (group 2) and patients treated with continuous positive airway pressure (group 5) (p = 0.008, p = 0.008 and p = 0.003). Minimum oxygen saturation values of group 4 were significantly lower than those of groups 1, 2 and 5 (p = 0.0005, p = 0.011 and p = 0.001). There was a positive correlation between apnoea–hypopnea index and neutrophil-to-lymphocyte ratio (r = 0.758, p = 0.034), and a negative correlation between apnoea–hypopnea index and minimum oxygen saturation (r = −0.179, p = 0.012).


Neutrophil-to-lymphocyte ratio may be used to determine disease severity, complementing polysomnography.

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Copyright © JLO (1984) Limited 2015 

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