Skip to main content
×
Home
    • Aa
    • Aa

Active surveillance management of head and neck paragangliomas: case series and review of the literature

  • L Harrison (a1) and R Corbridge (a2)
Abstract
Abstract Background:

Head and neck paragangliomas are rare. They are usually slow-growing, benign, non-catecholamine secreting tumours, traditionally treated with surgical excision. Complications of surgical excision include lower cranial nerve palsies, stroke and death.

Method:

A retrospective case note analysis was conducted of patients with head and neck paragangliomas treated with a watch-and-scan policy from March 2003 to September 2015, and the relevant literature was reviewed.

Results:

Fifteen head and neck paragangliomas were identified. None of the patients developed a new lower cranial nerve palsy or progression of their presenting hearing loss during the follow-up period. Five patients displayed an increase in maximum linear dimension of 4 mm over an average of 57.4 months. A review of the literature showed that a watch-and-surveillance scan policy is evolving as a treatment option for head and neck paragangliomas without malignant risk factors.

Conclusion:

Readily available surveillance scanning in head and neck paragangliomas enables the monitoring of head and neck paragangliomas, which may allow for avoidance of major surgery.

Copyright
Corresponding author
Address for correspondence: Ms Laura Harrison, Department of ENT, Head and Neck Surgery, Northampton General Hospital, Northampton, UK E-mail: lauraharrison707@gmail.com
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2 R. Van den Berg Imaging and management of head and neck paragangliomas. Eur Radiol 2005;15:1310–18

3 B Havekes , EP Corssmit , JC Jansen , AG van der Mey , AH Vriends , JA Romijn Malignant paragangliomas associated with mutations in the succinate dehydrogenase D gene. J Clin Endocrinol Metab 2007;92:1245–8

4 CC Boedeker , HP Neumann , W Maier , B Bausch , J Schipper , GJ. Ridder Malignant head and neck paragangliomas in SDHB mutation carriers. Otolaryngol Head Neck Surg 2007;137:126–9

5 P Patetsios , DR Gable , WW Garrett , JP Lamont , JA Kuhn , WP Shutze Management of carotid body paragangliomas and review of a 30-year experience. Ann Vasc Surg 2002;16:331–8

6 DB Chapman , D Lippert , CP Geer , HD Edwards , GB Russell , CJ Rees Clinical, histopathologic, and radiographic indicators of malignancy in head and neck paragangliomas. Otolaryngol Head Neck Surg 2010;143:531–7

7 KB Samji , AL Crown , MS Buxton-Thomas , SJ Aylwin , KM Schulte , S. Dizdarevic Necessity for long-term follow-up of patients with head and neck paraganglioma and mutation in the succinate dehydrogenase genes: an index case report and literature review. Endocr Pract 2012;18:e1304

8 RJ Obholzer , R Hornigold , S Connor , MJ. Gleeson Classification and management of cervical paragangliomas. Ann R Coll Surg Engl 2011;93:596602

9 JL Netterville , CG Jackson , FR Miller , JR Wanamaker , ME. Glasscock Vagal paraganglioma: a review of 46 patients treated during a 20-year period. Arch Otolaryngol Head Neck Surg 1998;124:1133–40

10 CG. Jackson Glomus tympanicum and glomus jugulare tumours. Otolaryngol Clin North Am 2001;34:941–70

11 AJ Krych , RL Foote , PD Brown , YI Garces , MJ. Link Long-term results of irradiation for paraganglioma. Int J Radiat Oncol Biol Phys 2006;65:1063–6

12 J Kunzel , J de Tristan , K Mantsopoulos , M Koch , M Baussmerth , J Zenk Experiences in the treatment of patients with multiple head and neck paragangliomas. Am J Otolaryngol 2014;35:294–9

13 ML Carlson , AD Sweeney , GB Wanna , JL Netterville , DS. Haynes Natural history of glomus jugulare: a review of 16 tumours managed with primary observation. Otolaryngol Head Neck Surg 2015;152:98105

17 EE Lack , AL Cubilla , JM Woodruff , HW. Farr Paragangliomas of the head and neck region: a clinical study of 69 patients. Cancer 1977;39:397409

18 N Van Duinen , D Steenvoorden , IP Kema , JC Jansen , AH Vriends , JP Bayley Increased urinary extraction of 3-methoxytyramine in patients with head and neck paragangliomas. J Clin Endocrinol Metab 2010;95:209–14

19 MJ Saldana , LE Salem , R. Travezan High altitude hypoxia and chemodectomas. Hum Pathol 1973;4:251–63

21 BE. Baysal Hereditary paraganglioma targets diverse paraganglia. J Med Genet 2002;39:617–22

22 N Burnichon , N Abermil , A Buffet , J Favier , AP. Gimenez-Roqueplo The genetics of paragangliomas. Eur Ann Otorhinolaryngol Head Neck Dis 2012;129:315–18

23 CG Jackson , BM McGrew , JA Forest , JL Netterville , CF Hampf , ME Glasscock 3rd. Lateral skull base surgery for glomus tumors: long-term control. Otol Neurotol 2001;22:377–82

24 D. Heath The human carotid body in health and disease. J Pathol 1991;164:18

25 EP Corssmit , JA. Romijn Clinical management of paragangliomas. Eur J Endocrinol 2014;171:R23143

26 D Taieb , A Kaliski , CC Boedeker , V Martucci , T Fojo , JR Adler Jr Current approaches and recent developments in the management of head and neck paragangliomas. Endocr Rev 2014;35:795819

28 DM Neskey , G Hatoum , R Modh , F Civantos , FF Telischi , SI Angeli Outcomes after surgical resection of head and neck paragangliomas: a review of 61 patients. Skull Base 2011;21:171–6

29 J Fish , MD Klein-Weigel , M Biebl , A Janecke , T Tauscher , G. Fraedrich Systematic screening and treatment evaluation of hereditary neck paragangliomas. Head Neck 2007;29:864–73

30 J de Flines , J Jansen , R Elders , M Siemers , A Vriends , F Hes Normal life expectancy for paraganglioma patients: a 50-year-old cohort revisited. Skull Base 2011;21:385–8

31 P Piazza , F Di Lella , A Bacciu , G Di Trapani , H Ait Mimoune , M. Sanna Preoperative protective stenting of the internal carotid artery in the management of complex head and neck paragangliomas: long-term results. Audiol Neurootol 2015;18:345–52

32 RS Sethi , RK Sethi , MW Herr , DG. Deschler Malignant head and neck paragangliomas: treatment efficacy and prognostic indicators. Am J Otolaryngol 2013;34:431–8

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 5
Total number of PDF views: 34 *
Loading metrics...

Abstract views

Total abstract views: 100 *
Loading metrics...

* Views captured on Cambridge Core between 17th April 2017 - 20th August 2017. This data will be updated every 24 hours.