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Cervical lymph node metastasis in adenoid cystic carcinoma of the major salivary glands

  • INTERNATIONAL HEAD AND NECK SCIENTIFIC GROUP (a1)
Abstract
Abstract Objective:

To verify the prevalence of cervical lymph node metastasis in adenoid cystic carcinoma of major salivary glands, and to establish recommendations for elective neck treatment.

Methods:

A search was conducted of the US National Library of Medicine database. Appropriate articles were selected from the abstracts, and the original publications were obtained to extract data.

Results:

Among 483 cases of major salivary gland adenoid cystic carcinoma, a total of 90 (18.6 per cent) had cervical metastasis. The prevalence of positive nodes from adenoid cystic carcinoma was 14.5 per cent for parotid gland, 22.5 per cent for submandibular gland and 24.7 per cent for sublingual gland. Cervical lymph node metastasis occurred more frequently in patients with primary tumour stage T3–4 adenoid cystic carcinoma, and was usually located in levels II and III in the neck.

Conclusion:

Adenoid cystic carcinoma of the major salivary glands is associated with a significant prevalence of cervical node metastasis, and elective neck treatment is indicated for T3 and T4 primary tumours, as well as tumours with other histological risk factors.

Copyright
Corresponding author
Address for correspondence: Prof Alfio Ferlito, Via Firenze 11, 35031 Selvazzano Dentro, Padova, Italy E-mail: a.ferlito@uniud.it
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* See Authorship section for full list of collaborators.
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1 K Bjørndal , A Krogdahl , MH Therkildsen , J Overgaard , J Johansen , CA Kristensen Salivary gland carcinoma in Denmark 1990–2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Group (DAHANCA). Oral Oncol 2011;47:677–82

2 M Amit , Y Binenbaum , K Sharma , N Ramer , I Ramer , A Agbetoba Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study. Head Neck 2015;37:1032–7

3 M Amit , S Na'ara , K Sharma , N Ramer , I Ramer , A Agbetoba Elective neck dissection in patients with head and neck adenoid cystic carcinoma: an international collaborative study. Ann Surg Oncol 2015;22:1353–9

4 T Beppu , SE Kamata , K Kawabata , T Nigauri , H Mitani , S Yoshimoto Prophylactic neck dissection for submandibular gland cancer [in Japanese]. Nihon Jibiinkoka Gakkai Kaiho 2003;106:831–7

5 RJ Postema , ML van Velthuysen , MW van den Brekel , AJ Balm , JL. Peterse Accuracy of fine-needle aspiration cytology of salivary gland lesions in the Netherlands Cancer Institute. Head Neck 2004;26:418–24

6 P Zbären , J Schüpbach , M Nuyens , E. Stauffer Elective neck dissection versus observation in primary parotid carcinoma. Otolaryngol Head Neck Surg 2005;132:387–91

7 I Régis De Brito Santos , LP Kowalski , V Cavalcante De Araujo , Logullo A Flávia , J. Magrin Multivariate analysis of risk factors for neck metastases in surgically treated parotid carcinomas. Arch Otolaryngol Head Neck Surg 2001;127:5660

8 E Stennert , D Kisner , M Jungehuelsing , O Guntinas-Lichius , U Schröder , HE Eckel High incidence of lymph node metastasis in major salivary gland cancer. Arch Otolaryngol Head Neck Surg 2003;129:720–3

9 RH Spiro , AG. Huvos Stage means more than grade in adenoid cystic carcinoma. Am J Surg 1992;164:623–8

10 DE da Cruz Perez , Alves F de Abreu , Nishimoto I Nobuko , OP de Almeida , LP. Kowalski Prognostic factors in head and neck adenoid cystic carcinoma. Oral Oncol 2006;42:139–46

11 JG Armstrong , LB Harrison , HT Thaler , H Friedlander-Klar , DE Fass , MJ Zelefsky The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer 1992;69:615–19

12 T Ettl , M Gosau , G Brockhoff , S Schwarz-Furlan , A Agaimy , TE Reichert Predictors of cervical node metastasis in salivary gland cancer. Head Neck 2014;36:517–23

15 CH Terhaard , H Lubsen , CR Rasch , PC Levendag , HH Kaanders , RE Tjho-Heslinga The role of radiotherapy in the treatment of malignant salivary gland tumors. Int J Radiat Oncol Biol Phys 2005;61:103–11

16 S van Weert , E Bloemena , I van der Waal , R de Bree , DH Rietveld , JD Kuik Adenoid cystic carcinoma of the head and neck: a single-center analysis of 105 consecutive cases over a 30-year period. Oral Oncol 2013;49:824–9

17 Y Zhang , RH Xia , J Han , BS Wang , WD Tian , LP Zhong Adenoid cystic carcinoma of the head and neck: clinicopathologic analysis of 218 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:368–75

19 MK Bhayani , M Yener , A El-Naggar , A Garden , EY Hanna , RS Weber Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer 2012;118:2872–8

20 DJ Kelley , RH. Spiro Management of the neck in parotid carcinoma. Am J Surg 1996;172:695–7

21 R Min , L Siyi , Y Wenjun , A Ow , W Lizheng , D Minjun Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis: a preliminary study of 62 cases. Int J Oral Maxillofac Surg 2012;41:952–7

22 M Stenner , C Molls , JC Luers , D Beutner , JP Klussmann , KB. Huettenbrink Occurrence of lymph node metastasis in early-stage parotid gland cancer. Eur Arch Otorhinolaryngol 2012;269:643–8

23 YL Wang , DS Li , HL Gan , ZW Lu , H Li , GP Zhu Predictive index for lymph node management of major salivary gland cancer. Laryngoscope 2012;122:1497–506

24 CM Lim , M Gilbert , JT Johnson , S. Kim Is level V neck dissection necessary in primary parotid cancer? Laryngoscope 2015;125:118–21

25 JE. Medina Neck dissection in the treatment of cancer of major salivary glands. Otolaryngol Clin North Am 1998;31:815–22

26 AM Chen , J Garcia , NY Lee , MK Bucci , DW. Eisele Patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: what is the role of elective neck irradiation? Int J Radiat Oncol Biol Phys 2007;67:988–94

27 MP Herman , JW Werning , CG Morris , JM Kirwan , RJ Amdur , WM. Mendenhall Elective neck management for high-grade salivary gland carcinoma. Am J Otolaryngol 2013;34:205–8

28 RH Spiro , SI Hajdu , EW. Strong Tumors of the submaxillary gland. Am J Surg 1976;132:463–8

29 JL Roh , SH Choi , SW Lee , KJ Cho , SY Nam , SY. Kim Carcinomas arising in the submandibular gland: high propensity for systemic failure. J Surg Oncol 2008;97:533–7

31 MS Allen Jr, WL Marsh Jr. Lymph node involvement by direct extension in adenoid cystic carcinoma. Absence of classic embolic lymph node metastasis. Cancer 1976;38:2017–21

32 PM Stell , AH Cruickshank , PJ Stoney , MS. McCormick Lymph node metastases in adenoid cystic carcinoma. Am J Otolaryngol 1985;6:433–6

33 HM Matsuba , JR Simpson , M Mauney , SE. Thawley Adenoid cystic salivary gland carcinoma: a clinicopathologic correlation. Head Neck Surg 1986;8:200–4

34 RR Seethala , JL Hunt , ZW Baloch , VA Livolsi , LE. Barnes Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol 2007;31:1683–94

35 A Bosch , JH Brandenburg , KW. Gilchrist Lymph node metastases in adenoid cystic carcinoma of the submaxillary gland. Cancer 1980;45:2872–7

36 PR Seaver Jr, PG. Kuehn Adenoid cystic carcinoma of the salivary glands. A study of ninety-three cases. Am J Surg 1979;137:449–55

37 N Munir , PJ. Bradley Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol 2008;44:251–60

38 AN Cohen , EJ Damrose , RY Huang , SD Nelson , KE Blackwell , TC. Calcaterra Adenoid cystic carcinoma of the submandibular gland: a 35-year review. Otolaryngol Head Neck Surg 2004;131:9941000

39 MW Han , KJ Cho , JL Roh , SH Choi , SY Nam , SY. Kim Patterns of lymph node metastasis and their influence on outcomes in patients with submandibular gland carcinoma. J Surg Oncol 2012;106:475–80

40 RS Weber , RM Byers , B Petit , P Wolf , K Ang , M. Luna Submandibular gland tumors. Adverse histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg 1990;116:1055–60

41 SM Kaszuba , ME Zafereo , DI Rosenthal , AK El-Naggar , RS. Weber Effect of initial treatment on disease outcome for patients with submandibular gland carcinoma. Arch Otolaryngol Head Neck Surg 2007;133:546–50

42 R Zdanowski , FL Dias , MM Barbosa , RA Lima , PA Faria , AM Loyola Sublingual gland tumors: clinical, pathologic, and therapeutic analysis of 13 patients treated in a single institution. Head Neck 2011;33:476–81

43 RM Rankow , F. Mignogna Cancer of the sublingual salivary gland. Am J Surg 1969;118:790–5

44 G Sun , X Yang , E Tang , J Wen , M Lu , Q. Hu The treatment of sublingual gland tumours. Int J Oral Maxillofac Surg 2010;39:863–8

45 LJ Andersen , MH Therkildsen , HH Ockelmann , JD Bentzen , T Schiødt , HS. Hansen Malignant epithelial tumors in the minor salivary glands, the submandibular gland, and the sublingual gland. Prognostic factors and treatment results. Cancer 1991;68:2431–7

46 RH. Spiro Treating tumors of the sublingual glands, including a useful technique for repair of the floor of the mouth after resection. Am J Surg 1995;170:457–60

47 DE Perez , FR Pires , A Alves Fde , OP Almeida , LP. Kowalski Sublingual salivary gland tumors: clinicopathologic study of six cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:449–53

48 T Yu , QH Gao , XY Wang , YM Wen , LJ. Li Malignant sublingual gland tumors: a retrospective clinicopathologic study of 28 cases. Oncology 2007;72:3944

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
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