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Evaluation of epithelial proliferation in paediatric and adult cholesteatomas using the Ki-67 proliferation marker

Published online by Cambridge University Press:  14 December 2011

K Sikka ,
S C Sharma ,
A Thakar  and
S Dattagupta
K Sikka
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
S C Sharma*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
A Thakar
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
S Dattagupta
Affiliation:
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
*
Address for correspondence: Professor S C Sharma, Head, Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi 110029, India E-mail: suresh6sharma@yahoo.com
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Abstract

Introduction:

The aggressiveness of cholesteatoma in children compared with adults is well known. However, the factors influencing the poorer prognosis of paediatric cholesteatoma are not well understood. This study compared the proliferative potential of paediatric cholesteatoma with that of adult cholesteatoma, using Ki-67 as a proliferation marker.

Methods:

A prospective study of 67 patients with aural cholesteatoma was performed. Thirty-eight adult and 29 paediatric cases were evaluated using clinical parameters including bone erosion, complications and extent of disease. A surgical specimen underwent histological evaluation and measurement of the proliferation index using Ki-67 labelling. Normal epithelium from a control group was also examined.

Results:

Cholesteatoma epithelium has a greater rate of proliferation than normal skin. There were however no statistical differences between the paediatric and adult cholesteatoma groups in terms of clinical behaviour or proliferation potential. Paediatric cholesteatoma was similar to adult cholesteatoma in terms of complications, bone erosion and disease spread.

Conclusion:

Cholesteatoma is a disorder of epithelial proliferation. Although postulated to be more aggressive in children than adults, this study found no clinicopathological differences between paediatric and adult cases.

Keywords

CholesteatomaChildCellular ProliferationPathology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 5 , May 2012 , pp. 460 - 463
Copyright
Copyright © JLO (1984) Limited 2011

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