Hostname: page-component-76fb5796d-x4r87 Total loading time: 0 Render date: 2024-04-27T07:10:30.272Z Has data issue: false hasContentIssue false
  • English
  • Français

Hormonal changes causing rhinitis in pregnancy among Malaysian women

Published online by Cambridge University Press:  19 August 2013

B Indirani ,
R Raman  and
S Z Omar
B Indirani
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
R Raman*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
S Z Omar
Affiliation:
Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
*
Address for correspondence: Professor Rajagopalan Raman, Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia Fax: +603 79556963 E-mail: ramanr_99@yahoo.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives:

To investigate the aetiology of rhinitis occurring in pregnancy, by (1) describing the relationship between pregnancy rhinitis and serum oestrogen, progesterone, placental growth hormone and insulin-like growth factor, and (2) assessing the prevalence of pregnancy rhinitis among Malaysian women.

Methods:

Prospective study involving 30 pregnant women followed at an ante-natal clinic for 14 months. Hormone levels were analysed during pregnancy and the post-partum period.

Results:

Levels of all four hormones were elevated in the third trimester, compared with first trimester and post-partum values. Rhinitis patients had higher levels of oestrogen and insulin-like growth factor 1 in the third trimester than non-rhinitis patients, although these differences were not statistically significant. The prevalence of rhinitis was 53.3 per cent, with most cases occurring in the third trimester. Patients with pregnancy rhinitis had a higher prevalence of female babies, compared with non-rhinitis patients (p = 0.003).

Conclusions:

Pregnancy rhinitis was significantly more common in women giving birth to female babies. Women with pregnancy rhinitis had a non-significant elevation in oestrogen and insulin-like growth factor 1 levels, compared with those without rhinitis.

Keywords

PregnancyRhinitisEstrogenProgesteronePlacental-Specific Growth HormoneHumanInsulin Like Growth Factor 1
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 9 , September 2013 , pp. 876 - 881
Copyright
Copyright © JLO (1984) Limited 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Silva, AL, Silva, AB, Stankiewicz, JA. Nasal obstruction in pregnancy. Primary Care Update for Ob/Gyns 1995;2:37–44CrossRefGoogle Scholar
2Ellegard, EK, Oscarsson, J, Bougoussa, M, Igout, A, Hemen, G, Eden, S et al. Serum level of placental growth hormone is raised in pregnancy rhinitis. Arch Otolaryngol Head Neck Surg 1998;124:439–43CrossRefGoogle ScholarPubMed
3Mabry, RL. Rhinitis of pregnancy. South Med J 1986;79:965–71CrossRefGoogle ScholarPubMed
4Philpott, CM, Conboy, P, Al Azzawi, F, Murty, G. Nasal physiological changes during pregnancy. Clin Otolaryngol 2004;29:343–51CrossRefGoogle ScholarPubMed
5Mashagbeh, M, Sbaihat, A, Harahsheh, H. Rhinitis during pregnancy: risk factors and management. Middle Eastern Journal of Family Medicine 2010;8:3–5Google Scholar
6Mortimer, H, Wright, RP, Collin, JB. The effect of the administration of estrogenic hormones on the nasal mucosa of the monkey (Macaca mulatta). Can Med Assoc J 1936;35:503–13Google ScholarPubMed
7Hansson, HA, Jorgensen, F, Petruson, B, Petruson, K. Regenerating human nasal mucosa cells express peptide growth factors. Arch Otolaryngol Head Neck Surg 1991;117:1368–77CrossRefGoogle ScholarPubMed
8Turnbull, AC, Patten, PT, Flint, AP, Keirse, MJNC, Jeremy, JY, Anderson, ABM. Significant fall in progesterone and rise in oestradiol levels in human peripheral plasma before onset of labour. Lancet 1974;i:101–3CrossRefGoogle Scholar
9Asher, MI, Keil, U, Anderson, HR, Beasley, R, Crane, J, Martinez, F et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 1995;8:483–91CrossRefGoogle Scholar
10Kletzky, OA, Rossman, F, Bertolli, SI, Platt, LD, Mishell, DR. Dynamics of human chorionic gonadotropin, prolactin and growth hormone in serum and amniotic fluid throughout normal human pregnancy. Am J Obstet Gynecol 1985;151:878–84CrossRefGoogle ScholarPubMed
11Alsat, E, Guibourdenche, J, Couturier, A, Brion, DE. Physiological role of human placental growth hormone. Mol Cell Endocrinol 1998;140:121–7CrossRefGoogle ScholarPubMed
12Ellegard, EK. Clinical and pathogenetic characteristic of pregnancy rhinitis. Clinical Reviews in Allergy and Immunology 2004;26:149–59CrossRefGoogle ScholarPubMed
13Longo, LD. Maternal blood volume and cardiac output during pregnancy: a hypothesis of endocrinologic control. AJP Reg Physiol 1983;245:720–9Google ScholarPubMed
14Ellegard, EK. Pregnancy, rhinitis. Immunol Allergy Clin N Am 2006;26:119 –35CrossRefGoogle Scholar
15Incaudo, GA, Takach, P. The diagnosis and treatment of allergic rhinitis during pregnancy and lactation. Immunol Allergy Clin N Am 2006;26:137–54CrossRefGoogle ScholarPubMed
16Sharma, K, Sharma, S, Chander, D. Evaluation of audio rhinological changes during pregnancy. Indian J Otolaryngol Head Neck Surg 2009;63:74–8CrossRefGoogle Scholar
17Bidlingmaier, F. Sex differences in the secretion of gonadotropins and sex hormones in newborns and infants. Fortschr Med 1980;98:235–8Google ScholarPubMed