Hostname: page-component-848d4c4894-8bljj Total loading time: 0 Render date: 2024-06-16T11:00:56.037Z Has data issue: false hasContentIssue false
  • English
  • Français

Laryngeal paraganglioma in an irradiated neck

Published online by Cambridge University Press:  29 May 2012

T A Pham ,
R De Freitas ,
G Young  and
A Safdar
T A Pham*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Monash Medical Centre, Victoria, Australia
R De Freitas
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Monash Medical Centre, Victoria, Australia
G Young
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Monash Medical Centre, Victoria, Australia
A Safdar
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Monash Medical Centre, Victoria, Australia
*
Address for correspondence: Dr Truong An Pham, Department of Surgery, Peninsula Health, 15-17 Davey St., Frankston, Victoria, Australia3199 E-mail: an.pham@live.com.au
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

We present the first reported case of a paraganglioma of the larynx occurring concurrently with squamous cell carcinoma in an irradiated neck.

Method:

We present a case report and a literature review of paraganglioma of the larynx.

Case report:

A 78-year-old woman was found to have a mass on the laryngeal surface of the epiglottis and non-functioning larynx, four months after radical radiotherapy for biopsy-proven squamous cell carcinoma. Repeated positron emission tomography computed tomography was highly suggestive of residual malignancy. Given these findings, and the fact that the patient was aspirating, she was treated with total laryngectomy, and was found to have a paraganglioma of the larynx.

Conclusion:

This is the first report of such a case. Its importance is three-fold in that it demonstrates: the coexistence of paraganglioma and squamous cell carcinoma; the difficulties that can be encountered in the diagnosis; and the use of radiotherapy in the treatment of paraganglioma.

Keywords

ParagangliomaLarynxLaryngectomySquamous Cell Carcinoma
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 7 , July 2012 , pp. 747 - 750
Copyright
Copyright © JLO (1984) Limited 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Ferlito, A, Barnes, L, Rinaldo, A, Gnepp, DR, Milroy, CM.A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment. J Laryngol Otol 2007;112:827–34CrossRefGoogle Scholar
2Snyderman, C, Lin, D. Paragangliomas of the head and neck. In: Basow, DS, ed. UptoDate. Waltham, Massachusetts: 2010Google Scholar
3Ferlito, A, Silver, CE, Bradford, CR, Rinaldo, A.Neuroendocrine neoplasms of the larynx: an overview. Head Neck 2009;31:1634–46CrossRefGoogle ScholarPubMed
4Blanchard, C, Saunders, W.Chemodectoma of the larynx; case report. AMA Arch Otolaryngol 1955;61:472–4CrossRefGoogle ScholarPubMed
5Peterson, K, Fu, Y, Calcaterra, T.Subglottic paraganglioma. Head Neck 1997;19:54–63.0.CO;2-R>CrossRefGoogle ScholarPubMed
6Ferlito, A, Barnes, L, Wenig, BM.Identification, classification, treatment, and prognosis of laryngeal paraganglioma. Review of the literature and eight new cases. Ann Otol Rhinol Laryngol 1994;103:525–36CrossRefGoogle ScholarPubMed
7Myssiorek, D, Rinaldo, A, Barnes, L, Ferlito, A.Laryngeal paraganglioma: an updated critical review. Acta Otolaryngol 2004;124:995–9CrossRefGoogle ScholarPubMed
8Sanders, KW, Abreo, F, Rivera, E, Stucker, FJ, Nathan, CA.A diagnostic and therapeutic approach to paragangliomas of the larynx. Arch Otolaryngol Head Neck Surg 2001;127:565–9CrossRefGoogle ScholarPubMed
9Rubin, AD, Cheng, SS, Bradford, CR.Laryngeal paraganglioma in a patient with multiple head and neck paragangliomas. Otolaryngol Head Neck Surg 2005;132:520–2CrossRefGoogle Scholar
10Barnes, L.Paraganglioma of the larynx. A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 1991;53:220–34CrossRefGoogle ScholarPubMed
11Barnes, L, Ferlito, A, Wenig, BM.Laryngeal paragangliomas. A review and report of a single case. J Laryngol Otol 1997;111:197–8CrossRefGoogle ScholarPubMed
12Ferlito, A, Milroy, CM, Wenig, BM, Barnes, L, Silver, CE.Laryngeal paraganglioma versus atypical carcinoid tumor. Ann Otol Rhinol Laryngol 1995;104:78–83CrossRefGoogle ScholarPubMed
13Smolarz, JR, Hanna, EY, Williams, MD, Kupferman, ME.Paraganglioma of the endolarynx: a rare tumor in an uncommon location. Head Neck Oncol 2010;2:2CrossRefGoogle Scholar
14Laudadio, P.Chemodectoma (paraganglioma, nonchromaffin) of the superior glomus laryngeus [in Italian]. Otorinolaringol Ital 1972;39:19–31Google ScholarPubMed
15Lustrin, ES, Palestro, C, Vaheesan, K.Radiographic evaluation and assessment of paragangliomas. Otolaryngol Clin North Am 2001;34:881–906CrossRefGoogle ScholarPubMed
16Timmers, HJLM, Chen, CC, Carrasquillo, JA, Whatley, M, Ling, A, Havekes, B et al. Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma. J Clin Endocrinol Metab 2009;94:4757–67CrossRefGoogle ScholarPubMed
17Takayama, M, Konishi, K, Kishimoto, C, Kanazawa, A, Yamane, H.A case of cervical paraganglioma: usefulness of FDG PET imaging and a possibility of rare origination. Acta Otolaryngol Suppl 2004;554:81–5CrossRefGoogle Scholar
18Fiebrich, H-B, Brouwers, AH, Kerstens, MN, Pijl, MEJ, Kema, IP, de Jong, JR et al. 6-[F-18]Fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to conventional imaging with (123)I-metaiodobenzylguanidine scintigraphy, computer tomography, and magnetic resonance imaging in localizing tumors causing catecholamine excess. J Clin Endocrinol Metab 2009;94:3922–30CrossRefGoogle ScholarPubMed
19Hinerman, RW, Amdur, RJ, Morris, CG, Kirwan, J, Mendenhall, WM.Definitive radiotherapy in the management of paragangliomas arising in the head and neck: a 35-year experience. Head Neck 2008;30:1431–8CrossRefGoogle ScholarPubMed
20Mendenhall, WM, Amdur, RJ, Vaysberg, M, Mendenhall, CM, Werning, JW.Head and neck paragangliomas. Head Neck 2011;33:1530–4CrossRefGoogle ScholarPubMed