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Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison

Published online by Cambridge University Press:  14 February 2013

J Li ,
L Yu ,
R Xia ,
F Gao ,
W Luo  and
Y Jing
J Li
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, China
L Yu*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, China
R Xia
Affiliation:
Department of Radiology and Molecular Imaging Center, West China Hospital, Sichuan University, Chengdu City, China
F Gao
Affiliation:
Department of Radiology and Molecular Imaging Center, West China Hospital, Sichuan University, Chengdu City, China
W Luo
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Chongqing University of Medical Sciences, China
Y Jing
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, China
*
Address for correspondence: Dr Lisheng Yu, 11 Xizhimen South Street, Xicheng District, Beijing City, 100044, China Fax: +86 10 68318386 E-mail: yulish68@yahoo.com.cn
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Abstract

Background:

To investigate the feasibility of postauricular hypodermic injection for treating inner ear disorders, we compared perilymph pharmacokinetics for postauricular versus intravenous injection, using magnetic resonance imaging, in an animal model.

Methods:

Twelve albino guinea pigs were divided randomly into two groups and administered gadopentetate dimeglumine via either a postauricular or an intravenous bolus injection. A 7.0 Tesla magnetic resonance imaging system was used to assess the signal intensities of gadolinium-enhanced images of the cochlea, as a biomarker for changes in gadopentetate dimeglumine concentration in the perilymph. Pharmacokinetic parameters were calculated based on these signal intensity values.

Results:

Guinea pigs receiving postauricular injection showed longer times to peak signal intensity, longer elimination half-life, longer mean residence time and a greater area under the signal–time curve (from pre-injection to the last time point) (p < 0.05).

Conclusion:

Postauricular injection shows potential as an efficient drug delivery route for the treatment of inner ear disorders.

Keywords

Ear, InnerPerilymphAdministration, TranscutaneousPharmacokineticsGadoliniumMagnetic Resonance Imaging
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 3 , March 2013 , pp. 239 - 245
Copyright
Copyright © JLO (1984) Limited 2013

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