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The role of budesonide intrapolyp injection in the management of type 2 chronic rhinosinusitis with nasal polyps: a randomised clinical trial

Published online by Cambridge University Press:  02 October 2023

Saad Elzayat ,
Ahmed Elgendy ,
Hesham Lasheen ,
Mohamed E El-Deeb Open the ORCID record for Mohamed E El-Deeb [Opens in a new window] ,
Mohammad Mahmoud Aouf Open the ORCID record for Mohammad Mahmoud Aouf [Opens in a new window]  and
Ibrahim Gehad Open the ORCID record for Ibrahim Gehad [Opens in a new window]
Saad Elzayat
Affiliation:
Otorhinolaryngology Department, Faculty of Medicine – Kafrelsheikh University, Kafr ElSheikh, Egypt
Ahmed Elgendy
Affiliation:
Otorhinolaryngology Department, Faculty of Medicine – Kafrelsheikh University, Kafr ElSheikh, Egypt
Hesham Lasheen
Affiliation:
Otorhinolaryngology Department, Faculty of Medicine – Cairo University, Cairo, Egypt.
Mohamed E El-Deeb
Affiliation:
Otorhinolaryngology Department, Faculty of Medicine – Kafrelsheikh University, Kafr ElSheikh, Egypt
Mohammad Mahmoud Aouf
Affiliation:
Otorhinolaryngology Department, Faculty of Medicine – Kafrelsheikh University, Kafr ElSheikh, Egypt
Ibrahim Gehad*
Affiliation:
Otorhinolaryngology Department, Faculty of Medicine – Kafrelsheikh University, Kafr ElSheikh, Egypt
*
Corresponding author: Ibrahim Mahmoud Gehad; Email: ibrahimgehad94@gmail.com
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Abstract

Problem

To assess the efficacy of budesonide intrapolyp injection in chronic rhinosinusitis with nasal polyps.

Method

Ninety patients were divided into three groups; group A was given oral prednisolone, group B was given budesonide intrapolyp injection weekly for five consecutive weeks and group C was given budesonide as nasal irrigation for one month. Patients were assessed using Sino-Nasal Outcome Test 22 score, total nasal polyp score, serum immunoglobulin E, absolute eosinophilic count, and morning cortisol level before treatment, one week and three months after completing their treatment.

Results

Total nasal polyp score decreased significantly in all groups compared to those at baseline. Reduction in the oral and injection groups was greater than the wash group (p2 = 0.004), (p3 < 0.001), and the same trend concerning Sino-Nasal Outcome Test 22 score (p2 < 0.001), (p3 < 0.001).

Conclusion

Budesonide is an effective agent used in intrapolyp injection with no documented systemic or visual side effects that has comparable results with oral steroids.

Keywords

Nasal obstructionnasal polypsbudesonidesinusitiscorticosteroids
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 138 , Issue 4 , April 2024 , pp. 416 - 424
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Ibrahim Mahmoud Gehad takes responsibility for the integrity of the content of the paper

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