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Serum levels of interleukins 4 and 10 in head and neck squamous cell carcinoma

  • Z Mojtahedi (a1), B Khademi (a1), A Yehya (a1), A Talebi (a1), M J Fattahi (a1) and A Ghaderi (a1)...

Abstract

Objective:

There is currently controversy over the association between serum interleukin-4 and -10 levels and head and neck squamous cell carcinoma in patients of different ethnicity. This study aimed to investigate serum levels of these cytokines in Iranian patients with this pathology, and to analyse correlations with tumour location and tumour stage at diagnosis.

Design:

Serum cytokines levels were quantified using commercial enzyme-linked immunosorbent assays.

Subjects:

Study groups comprised 93 untreated patients and 53 healthy donors.

Results:

Serum interleukin-4 levels were significantly increased in patients compared with controls (p < 0.000), but were not significantly associated with tumour stage. Serum interleukin-10 levels were not raised in patients, nor associated with tumour stage.

Conclusion:

Serum levels of interleukin-4, but not -10, were increased in Iranian head and neck squamous cell carcinoma patients. These data do not support an association of these cytokines with tumour progression; this is consistent with previous findings.

Copyright

Corresponding author

Address for correspondence: Abbas Ghaderi, Professor of Immunology, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran Fax: 0098 711 2304952 E-mail: ghaderia@sums.ac.ir

References

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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