Phosphate of creosote is used medicinally under the name of Fosoto in Germany. The case described was that of a man, æt. 28, who took the drug for chest trouble. In all forty grammes, at a rate of three grammes a day, were taken. The medicine was then discontinued, and after ten days symptoms of polyneuritis began to develop. In the extremities subjective disturbances of sensibility were marked. These painful impressions were worse on movement or on pressure over the nerve trunks, but disappeared when the limbs were at rest. In from one to five days symptoms of loss of power made themselves manifest. In order of time the muscles of the leg were first affected, but the arms and hands were later involved, though not as severely as in the case of the lower extremities. Objective disturbances of the senses to touch, heat, and pain were slight, but followed the topographical distribution of the nerve trunks. These signs were followed by flaccidity of the muscles involved, which degenerated and to some extent atrophied. The skin became marbled in appearance, and desquamation took place.
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