♀, 36 years, was admitted into hospital, semi-comatose, without any history obtainable of the onset of her condition. She was very fat, with great pendulous masses on the upper arms, thighs, and abdomen, which gave the sensation on palpation of a bundle of worms, and which were very sensitive to pressure. With difficulty roused, her speech was noticed to be slow; she could not move her limbs. Vision was very bad, and there was marked optic neuritis. The previous history was: She had been growing fat for years; for six months she had complained of increasing difficulty in walking; two weeks before admission she suddenly lost power on the right side for a few hours; she then rapidly lost power in both legs and arms, and lost control of the sphincters. After several weeks' stay in the hospital she died—her symptoms varying but little. At the necropsy there was found a tumour of the pituitary body about the size of a walnut, involving the optic chiasma and protruding into the ventricles. The thyroid gland was normal in size, but contained a concretion the size of a small chestnut. The spinal cord showed a considerable degree of hydromyelia extending down to the dorsal region. Microscopically, there was found colloid degeneration of the thyroid with atrophy of secreting cells. There was evidence of nephritis and the ovaries were small and sclerosed. Discussing the case the author believes that the presence of the cerebral tumour was unrelated to the adiposis dolorosa, the pathology of which is obscure.
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