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Dye Free Determination of NASH in Human Liver Samples Using NAD(P)H Autofluorescence and Machine Learning Analysis

Published online by Cambridge University Press:  22 July 2022

Jonathan Boyd ,
Jada Domigue ,
Elizabeth A. Dozier  and
Taylor Cohen
Jonathan Boyd*
Affiliation:
AstraZeneca, Discovery Science, Gaithersburg, MD, USA
Jada Domigue
Affiliation:
AstraZeneca, Early Vaccines and Immune Therapies, Gaithersburg, MD, USA
Elizabeth A. Dozier
Affiliation:
AstraZeneca, Early Vaccines and Immune Therapies, Gaithersburg, MD, USA
Taylor Cohen
Affiliation:
AstraZeneca, Early Vaccines and Immune Therapies, Gaithersburg, MD, USA
*
*Corresponding author: Jonathan.boyd@astrazeneca.com

Abstract

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Type
Imaging, Microscopy, and Micro/Nano-Analysis of Pharmaceutical, Biopharmaceutical, and Medical Health Products - Research, Development, Analysis, Regulation, and Commercialization
Information
Microscopy and Microanalysis , Volume 28 , Supplement S1 , August 2022 , pp. 1434 - 1435
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Copyright
Copyright © Microscopy Society of America 2022

References

The NASH Education Program. NASH Global Health Observatory (NASH GHO) Survey. https://www.the-nash-education-program.com/news-medias/infographics/. Released in March 2017. Accessed February, 5 2022.Google Scholar
American Liver Foundation, https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/non-alcoholic-fatty-liver-disease/#1507301963329-e3720710-1909 Accessed February 3, 2022).Google Scholar
Scorletti, Eleonora, Carr, Rotonya M., “A new perspective on NAFLD: focusing on lipid droplets”, J Hepatol. 2021 Nov 15;S0168-8278 (21)02181-4. doi: 10.1016/j.jhep.2021.11.009.Google Scholar
BioIVT, https://bioivt.com/about Accessed February 3, 2022.Google Scholar
Cao, Ruofan, Wallrabe, Horst, Periasamy, Ammasi, “Multiphoton FLIM imaging of NAD(P)H and FAD with one excitation wavelength,” J. Biomed. Opt. 25(1), 014510 (2020), doi: 10.1117/1.JBO.25.1.014510CrossRefGoogle ScholarPubMed
Author, F, et al. , Conference Proceedings (year), p. 1.Google Scholar