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In Late-staged Atherosclerotic Foam Cells, Autophagy Exacerbates Lysosome Dysfunction and Cellular Homeostasis.

Published online by Cambridge University Press:  25 July 2016

W. Gray Jerome ,
Courtney Netherland-Van Dyke  and
Carrie Romer
W. Gray Jerome
Affiliation:
Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, USA
Courtney Netherland-Van Dyke
Affiliation:
Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, USA
Carrie Romer
Affiliation:
Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, USA

Abstract

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Type
Abstract
Information
Microscopy and Microanalysis , Volume 22 , Supplement S3: Proceedings of Microscopy & Microanalysis 2016 , July 2016 , pp. 1058 - 1059
Copyright
© Microscopy Society of America 2016 

References

[1] Singh, R, et al., Autophagy regulates lipid metabolism. Nature (2009) 458(7242) p. 1131–1135.CrossRefGoogle ScholarPubMed
[2] Klionsky, D, et al., Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2008) 4(2) p. 151–175.Google Scholar
[3] Cox, B, et al., Effects of cellular cholesterol loading on macrophage foam cell lysosome acidification. J Lipid Res (2007) 48, p. 1012–1021.CrossRefGoogle ScholarPubMed
[4] Jerome, W, et al., Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester. Microsc Microanal (2008) 14, p. 138–149.Google Scholar
[5] The authors acknowledge funding from NIH, NHLBI 5RO1HL86746 (WGJ), The American Heart Association Grant in Aid 15GRNT25700113 (WGJ), and The American Heart Association Postdoctoral Fellowship 13POST14240000 (CNV). Microscopy was supported in part by the VUMC Cell Imaging Shared Resource (supported by NIH grants CA68485, DK20593, DK58404, DK59637 and EY08126).Google Scholar