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Increasing Nitric Oxide Synthase in Human Renal Graft Rejection after Kidney Transplantation

Published online by Cambridge University Press:  02 July 2020

K. Seta ,
J. Papadimitriou ,
C. Drachenberg ,
M. R. Weir  and
C. Wei
K. Seta
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
J. Papadimitriou
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
C. Drachenberg
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
M. R. Weir
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
C. Wei
Affiliation:
Cardiorenal Molecular Research, Departments of Surgery, Medicine and Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201
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Extract

Nitric oxide (NO) is a potent endothelial-drived vasorelaxing factor and may involved in salt sensitive hypertension and renal damage. Nitric oxide is produced from L-arginine by activation of nitric oxide synthase (NOS). Three NOS has been identified which are brain NOS (bNOS), inducible NOS (iNOS) and endothelial NOS (eNOS). On the other hand, renal graft rejection is major problem after kidney transplantation with severe renal damage and renal vasoconstriction. While NOS has been reported localized in human and animal kidney, the status of three NOS in human renal tissue with rejection remains poorly defined. Therefore, the present study was designed to determine the expression of bNOS, iNOS and eNOS by immunohistochemical staining (IHCS) in human renal tissue with rejection and compared with that in normal human renal tissue.

Human renal biopsy (n=5) were obtained after kidney transplantation with mild and moderate renal rejection. Normal kidney biopsy was obtained during nephrectomy.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 616 - 617
Copyright
Copyright © Microscopy Society of America

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References

References:

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5. This research was supported in part by grants from the NIH (HL03174 & HL61299, C. Wei), AHAMD, NKF and University of Maryland School of Medicine.Google Scholar