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Molecular Imaging of Biological Samples in Pharmaceutical Development Using Mass Spectrometry Imaging and Machine Learning

Published online by Cambridge University Press:  22 July 2022

Hang Hu ,
Hilary Brown ,
Daniela Mesa Sanchez  and
Julia Laskin
Hang Hu
Affiliation:
Purdue University, West Lafayette, Indiana, United States
Hilary Brown
Affiliation:
Purdue University, West Lafayette, Indiana, United States
Daniela Mesa Sanchez
Affiliation:
Purdue University, West Lafayette, Indiana, United States
Julia Laskin*
Affiliation:
Purdue University, West Lafayette, Indiana, United States
*
*Corresponding author: jlaskin@purdue.edu

Abstract

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Type
Imaging, Microscopy, and Micro/Nano-Analysis of Pharmaceutical, Biopharmaceutical, and Medical Health Products - Research, Development, Analysis, Regulation, and Commercialization
Information
Microscopy and Microanalysis , Volume 28 , Supplement S1 , August 2022 , pp. 1430 - 1431
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Copyright
Copyright © Microscopy Society of America 2022

References

Unsihuay, D, Sanchez, DM, Laskin, J. Quantitative Mass Spectrometry Imaging of Biological Systems. Annual Review of Physical Chemistry. 2021, 72, 307-329.10.1146/annurev-physchem-061020-053416CrossRefGoogle ScholarPubMed
Theodore, A. Spatial Metabolomics and Imaging Mass Spectrometry in the Age of Artificial Intelligence. Annual Review of Biomedical Data Science. 2020, 3, 61-87.Google Scholar
Hu, H, Yin, R, Brown, H, Laskin, J. Spatial Segmentation of Mass Spectrometry Imaging Data by Combining Multivariate Clustering and Univariate Thresholding. Analytical Chemistry. 2021, 93(7), 3477-3485.10.1021/acs.analchem.0c04798CrossRefGoogle ScholarPubMed
Hu, H, Bindu, JP, Laskin, J. Self-Supervised Clustering of Mass Spectrometry Imaging Data Using Contrastive Learning. Chemical Science. 2022, 13(1), 90-98.10.1039/D1SC04077DCrossRefGoogle Scholar
Brown, H, et al. Mass Spectrometry Imaging of Diclofenac and Its Metabolites in Tissues Using Nanospray Desorption Electrospray Ionization. ChemRxiv. 2020. doi: 10.26434/chemrxiv.13194422.v1Google Scholar