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Ultrafine Particles Penetrate Human Airway Epithelium Resulting in Increased Expression of Genes Causally Related to Cell Proliferation and Apoptosis

Published online by Cambridge University Press:  02 July 2020

K. BeruBe ,
C. Timblin ,
A. Shukla ,
A. Churg  and
B. Mossman
K. BeruBe
Affiliation:
School of Biosciences, Cardiff University, Cardiff, Wales, CF1 3, US
C. Timblin
Affiliation:
Department of Pathology, University of Vermont College of Medicine, Burlington, VT, 05405
A. Shukla
Affiliation:
Department of Pathology, University of Vermont College of Medicine, Burlington, VT, 05405
A. Churg
Affiliation:
Department of Laboratory Medicine, University of British Columbia, Vancouver, BC, VT6 2B5
B. Mossman
Affiliation:
Department of Pathology, University of Vermont College of Medicine, Burlington, VT, 05405
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Extract

Epidemiological studies have associated exposure to airborne particulate matter (PM) with an aerodynamic diameter less than 10 microns, especially the finer fraction PM2.5, with increases in morbidity and mortality in persons with preexisting cardiopulmonary disease. However, whether exposures to PM10 cause lung disease in uncompromised individuals is a topic of debate, especially since mechanistic and toxicological studies have failed to define cause and effect relationships between exposures to PM10 and phenotypic changes associated with the development of pulmonary diseases. PM10 is a complex mixture of soot and natural minerals, metal oxide particles, sea salt grains and aeroallergens (Fig. 1). Our interest lies with the carbonaceous components (Fig. 2), since insoluble particles may be more efficiently retained in the peripheral lung and be potentially more bioreactive due to their accumulation over time. We are interested in the ultrafine (UF) fraction (<1.0um diameter) since the number of particles in this size range are known to increase during pollution episodes and they have a greater reactive surface area per unit weight.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 580 - 581
Copyright
Copyright © Microscopy Society of America

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References

References:

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5. Research support was provided by DETR (UK) for CU and by NIEHS, NHLBI (USA) for UVM.Google Scholar