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Inhibition of BMP9 Induced Bone Formation by Salicylic-acid Polymer Capping

Published online by Cambridge University Press:  27 January 2020

Timothy M. Acri ,
Noah Z. Laird ,
Liu Hong ,
Jaidev L. Chakka ,
Kyungsup Shin ,
Satheesh Elangovan  and
Aliasger K. Salem
Timothy M. Acri
Affiliation:
University of Iowa, College of Pharmacy, 115 S. Grand Avenue Iowa City, Iowa
Noah Z. Laird
Affiliation:
University of Iowa, College of Pharmacy, 115 S. Grand Avenue Iowa City, Iowa
Liu Hong
Affiliation:
University of Iowa, College of Dentistry, 801 Newton Road Iowa City, Iowa
Jaidev L. Chakka
Affiliation:
University of Iowa, College of Pharmacy, 115 S. Grand Avenue Iowa City, Iowa
Kyungsup Shin
Affiliation:
University of Iowa, College of Dentistry, 801 Newton Road Iowa City, Iowa
Satheesh Elangovan
Affiliation:
University of Iowa, College of Dentistry, 801 Newton Road Iowa City, Iowa
Aliasger K. Salem*
Affiliation:
University of Iowa, College of Pharmacy, 115 S. Grand Avenue Iowa City, Iowa University of Iowa, College of Dentistry, 801 Newton Road Iowa City, Iowa
*
*(Email: aliasger-salem@uiowa.edu)
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Abstract

This work focuses on the development of a system to control the formation of bone to complement developments that have enabled potent regeneration of bony tissue. Scaffolds were fabricated with chemically modified RNA encoding for bone morphogenetic protein-9 (cmBMP9) and capped with salicylic acid (SA)-containing polymer (SAPAE). The goal was to determine if SAPAE could inhibit the formation of bone in a pilot animal study since cmBMP9 has been demonstrated to be highly effective in regenerating bone in a rat calvarial defect model. The results indicated that cmBMP9 increased bone formation (30% increase in area covered compared to control) and that SAPAE trended toward reducing the bone formation. These results suggest SAPAE could be useful as a chemical agent in reducing unwanted bone formation in implants loaded with cmBMP9.

Keywords

polymerbonebiomaterialbiomedical
Type
Articles
Information
MRS Advances , Volume 4 , Issue 64: International Materials Research Congress XXVIII , 2019 , pp. 3505 - 3512
Copyright
Copyright © Materials Research Society 2020 

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