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Microvasculature: An essential component for organ-on-chip systems

Published online by Cambridge University Press:  10 January 2014

Hyunjae Lee*
Affiliation:
Seoul National University; ummae3@snu.ac.kr
Minhwan Chung*
Affiliation:
Seoul National University; wireless0426@naver.com
Noo Li Jeon
Affiliation:
Seoul National University; njeon@snu.ac.kr
*
*These authors have contributed equally.
*These authors have contributed equally.
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Abstract

Improving the biological relevance of organs-on-chips is one of the main issues in biomedical engineering. The microvascular system is related to numerous biological phenomena throughout the life of organs. Although many in vitro microvascular systems have been developed, current organ-on-chip systems fail to fully integrate three-dimensional microvasculature, which results in decreased similarity of the systems with in vivo conditions. In this review, we propose that the microvascular system is an essential component for engineering organs-on-chips to achieve greater biological relevance. Various methods for engineering microvessels in vitro are reviewed, as well as recent representative efforts to engineer vascularized organs-on-chips. Material considerations for designing organs-on-chips are also reviewed.

Type
Research Article
Copyright
Copyright © Materials Research Society 2014 

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